The cellular immune response contributes to clearance of hepatitis C virus (HCV) and
persists for decades after recovery from infection. The immunological basis for the …

This study was performed to compare the vigor and phenotype of virus-specific CD4+ and
CD8+ T-cell responses in patients with different virologic and clinical outcomes after …

Chronic hepatitis C virus (HCV) infection is associated with impaired proliferative, cytokine,
and cytotoxic effector functions of HCV-specific CD8+ T cells that probably contribute …

The precise mechanisms responsible for the failure of intrahepatic hepatitis C virus (HCV)‐
specific CD8+ T cells to control the virus during persistent infection have not been fully …

Abstract Virus‐specific CD8+ T‐cells play an important role in the outcome of acute hepatitis
C virus (HCV) infection. In the chronic phase, however, HCV can persist despite the …

ABSTRACT A majority of patients infected with hepatitis C virus (HCV) do not sustain an
effective T-cell response, and viremia persists. The mechanism leading to failure of the HCV …

Abstract The CD4+ CD25+ regulatory T lymphocytes have been implicated in suppressing T
cell immune responses. Our aim was to characterize the frequency, phenotype, function, and …

Recent studies using MHC class I tetramers have shown that CD8+ T cell responses against
different persistent viruses vary considerably in magnitude and phenotype. At one extreme …

Since the discovery of hepatitis C virus it has become clear that chronic hepatitis C is a
major health problem throughout the world. Because antiviral agents are of limited value in …

Hepatitis C virus (HCV) sets up persistent infection in the majority of those exposed. It is
likely that, as with other persistent viral infections, the efficacy of T-lymphocyte responses …