Importance of the field: The evolution of targeted therapies is dependent upon identification
of cellular moieties that can be pharmacologically modulated. As one such example, the …

Background AKT, a critical effector of the phosphoinositide 3-kinase (PI3K) signalling
cascade, is an intensely pursued therapeutic target in oncology. Two distinct classes of AKT …

Targeted cancer therapies are used to inhibit the growth, progression, and metastasis of the
tumor by interfering with specific molecular targets and are currently the focus of anticancer …

The serine/threonine kinase AKT is a critical effector of the phosphoinositide 3-kinase (PI3K)
signaling cascade and has a pivotal role in cell growth, proliferation, survival, and …

Protein kinase B (Akt), similar to many other protein kinases, is at the crossroads of cell
death and survival, playing a pivotal role in multiple interconnected cell signaling …

Akt, also referred to as protein kinase B (PKB) or Related to A and C (RAC), is one of the
major direct downstream targets of phosphoinositide 3-kinase (PI3K). As it plays a central …

The discovery and optimization of a series of 6, 7-dihydro-5 H-cyclopenta [d] pyrimidine
compounds that are ATP-competitive, selective inhibitors of protein kinase B/Akt is reported …

Cancer is a devastating disease that has plagued humans from ancient times to this day.
After decades of slow research progress, promising drug development, and the identification …

The serine/threonine kinase Akt/PKB pathway presents an exciting new target for molecular
therapeutics, as it functions as a cardinal nodal point for transducing extracellular (growth …

Introduction: Targeted therapies in cancer aim to inhibit specific molecular targets
responsible for enhanced tumor growth. AKT/PKB (protein kinase B) is a serine threonine …