Many tumor cells rely on aerobic glycolysis instead of oxidative phosphorylation for their
continued proliferation and survival. Myc and HIF-1 are believed to promote such a …

Current drug development in oncology is non-selective as it typically focuses on pathways
essential for the survival of all dividing cells. The unique metabolic profile of cancer, which is …

High lactate generation and low glucose oxidation, despite normal oxygen conditions, are
commonly seen in cancer cells and tumors. Historically known as the Warburg effect, this …

Pyruvate is irreversibly decarboxylated to acetyl coenzyme A by mitochondrial pyruvate
dehydrogenase complex (PDC). Decarboxylation of pyruvate is considered a crucial step in …

Pyruvate dehydrogenase kinase PDK1 is a metabolic enzyme responsible for switching
glucose metabolism from mitochondrial oxidation to aerobic glycolysis in cancer cells, a …

Cancer cells use alterations of normal metabolic processes to sustain proliferation
indefinitely. Transcriptional and posttranscriptional control of the pyruvate dehydrogenase …

The switch of cellular metabolism from mitochondrial respiration to glycolysis is the hallmark
of cancer cells and associated with tumor malignancy. However, the mechanism of this …

Most solid tumors are characterized by a metabolic shift from glucose oxidation to glycolysis,
in part due to actively suppressed mitochondrial function, a state that favors resistance to …

During malignant progression cancer cells undergo a series of changes, which promote
their survival, invasiveness and metastatic process. One of them is a change in glucose …

Mitochondrial pyruvate dehydrogenase complex (PDC) is crucial for glucose homeostasis in
mammalian cells. The current understanding of PDC regulation involves inhibitory serine …