Taking a “good” look at free radicals in the aging process
S Hekimi, J Lapointe, Y Wen - Trends in cell biology, 2011 - cell.com
The mitochondrial free radical theory of aging (MFRTA) proposes that aging is caused by
damage to macromolecules by mitochondrial reactive oxygen species (ROS). This is based …
damage to macromolecules by mitochondrial reactive oxygen species (ROS). This is based …
When a theory of aging ages badly
J Lapointe, S Hekimi - Cellular and Molecular Life Sciences, 2010 - Springer
According to the widely acknowledged mitochondrial free radical theory of aging (MFRTA),
the macromolecular damage that results from the production of toxic reactive oxygen …
the macromolecular damage that results from the production of toxic reactive oxygen …
Mitochondrial Changes in Ageing Caenorhabditis elegans – What Do We Learn from Superoxide Dismutase Knockouts?
One of the most popular damage accumulation theories of ageing is the mitochondrial free
radical theory of ageing (mFRTA). The mFRTA proposes that ageing is due to the …
radical theory of ageing (mFRTA). The mFRTA proposes that ageing is due to the …
The mitochondrial free radical theory of aging: a critical view
A Sanz, RKA Stefanatos - Current aging science, 2008 - ingentaconnect.com
The Mitochondrial Free Radical Theory of Aging (MFRTA) proposes that mitochondrial free
radicals, produced as by-products during normal metabolism, cause oxidative damage …
radicals, produced as by-products during normal metabolism, cause oxidative damage …
A midlife crisis for the mitochondrial free radical theory of aging
JA Stuart, LA Maddalena, M Merilovich, EL Robb - Longevity & healthspan, 2014 - Springer
Since its inception more than four decades ago, the Mitochondrial Free Radical Theory of
Aging (MFRTA) has served as a touchstone for research into the biology of aging. The …
Aging (MFRTA) has served as a touchstone for research into the biology of aging. The …
[HTML][HTML] Mitochondrial reactive oxygen species: do they extend or shorten animal lifespan?
A Sanz - Biochimica et Biophysica Acta (BBA)-Bioenergetics, 2016 - Elsevier
Testing the predictions of the Mitochondrial Free Radical Theory of Ageing (MFRTA) has
provided a deep understanding of the role of reactive oxygen species (ROS) and …
provided a deep understanding of the role of reactive oxygen species (ROS) and …
Reactive Oxygen Species and Aging in Caenorhabditis elegans: Causal or Casual Relationship?
JM Van Raamsdonk, S Hekimi - Antioxidants & redox signaling, 2010 - liebertpub.com
The free radical theory of aging proposes a causal relationship between reactive oxygen
species (ROS) and aging. While it is clear that oxidative damage increases with age, its role …
species (ROS) and aging. While it is clear that oxidative damage increases with age, its role …
Oxidative stress and aging: beyond correlation
TR Golden, DA Hinerfeld, S Melov - Aging cell, 2002 - Wiley Online Library
The oxidative stress theory of aging has become increasingly accepted as playing a role in
the aging process, based primarily on a substantial accumulation of circumstantial evidence …
the aging process, based primarily on a substantial accumulation of circumstantial evidence …
Current methods in quantifying ROS and oxidative damage in Caenorhabditis elegans and other model organism of aging
CF Labuschagne, AB Brenkman - Ageing research reviews, 2013 - Elsevier
Accumulation of oxidative damage has been proposed to be causal to aging as defined by
the Free radical Theory of Aging, which has been subject to recent debate. However, a …
the Free radical Theory of Aging, which has been subject to recent debate. However, a …
Aging: All roads lead to mitochondria
Mitochondria were described as early as 1890 as ubiquitous intracellular structures by
Ernster and Schatz (1981)[1]. Since then, the accretion of knowledge in the past century has …
Ernster and Schatz (1981)[1]. Since then, the accretion of knowledge in the past century has …