Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes

R Janssen, L Bont, CLE Siezen… - Journal of Infectious …, 2007 - academic.oup.com
Background. Respiratory syncytial virus (RSV) is a common cause of severe lower
respiratory tract infection in infants. Only a proportion of children infected with RSV require …

Respiratory syncytial virus genotypes, host immune profiles, and disease severity in young children hospitalized with bronchiolitis

R Rodriguez-Fernandez, LI Tapia… - The Journal of …, 2018 - academic.oup.com
Background Data on how respiratory syncytial virus (RSV) genotypes influence disease
severity and host immune responses is limited. Here, we characterized the genetic variability …

Influence of Promoter Variants of Interleukin-10, Interleukin-9, and Tumor Necrosis Factor–α Genes on Respiratory Syncytial Virus Bronchiolitis

B Hoebee, L Bont, E Rietveld… - The Journal of …, 2004 - academic.oup.com
Previously, we reported genetic associations between severe respiratory syncytial virus
(RSV) bronchiolitis in infants and polymorphisms in the interleukin (IL)–4 and IL-4 receptor α …

Human genetic factors and respiratory syncytial virus disease severity

I Miyairi, JP DeVincenzo - Clinical microbiology reviews, 2008 - Am Soc Microbiol
To explain the wide spectrum of disease severity caused by respiratory syncytial virus (RSV)
and because of the limitations of animal models to fully parallel human RSV disease, study …

How respiratory syncytial virus genotypes influence the clinical course in infants hospitalized for bronchiolitis

F Midulla, R Nenna, C Scagnolari… - The Journal of …, 2019 - academic.oup.com
Background We aimed to study respiratory syncytial virus (RSV) genotype distribution,
clinical presentation, and disease severity in infants with bronchiolitis from RSV subtypes …

Cytokine gene polymorphisms moderate illness severity in infants with respiratory syncytial virus infection

DA Gentile, WJ Doyle, A Zeevi, J Howe-Adams… - Human immunology, 2003 - Elsevier
Illness severity and frequency of complications in infants with respiratory syncytial virus
(RSV) infection may be influenced by the local elaboration of cytokines. Cytokine gene …

Interleukin‐9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls

A Schuurhof, L Bont, CLE Siezen… - Pediatric …, 2010 - Wiley Online Library
The predominance of severe respiratory syncytial virus (RSV) bronchiolitis in boys
compared to girls is well known, but its mechanism is not yet understood. This is the first …

Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes

CLE Siezen, L Bont, HM Hodemaekers… - The Pediatric …, 2009 - journals.lww.com
Prematurity is a risk factor for severe respiratory syncytial virus bronchiolitis. We show that
genetic factors in innate immune genes (IFNA13, IFNAR2, STAT2, IL27, NFKBIA, C3, IL1RN …

Links between respiratory syncytial virus bronchiolitis and childhood asthma: clinical and research approaches

PJM Openshaw, GS Dean… - The Pediatric infectious …, 2003 - journals.lww.com
Thisreview examines the relationship between severe pulmonary disease caused by
respiratory syncytial virus (RSV) infection in infancy and later development of asthma or …

Association between common Toll-like receptor 4 mutations and severe respiratory syncytial virus disease

G Tal, A Mandelberg, I Dalal, K Cesar… - The Journal of …, 2004 - academic.oup.com
Background. The clinical spectrum of respiratory syncytial virus (RSV) bronchiolitis in
previously healthy infants is extremely variable. Thus, it is likely that factors such as genetic …