Receptors for Wingless and other signalling molecules of the Wnt gene family have yet to be
identified. We show here that cultured Drosophila cells transfected with a novel member of …

Secreted Wnt proteins have numerous signaling functions during development, mediated by
Frizzled molecules that act as Wnt receptors on the cell surface. In the genome ofDrosophila …

SUMMARY In Drosophila, two Frizzled proteins, Frizzled and Dfrizzled-2, have been
reported to serve as receptors of Wingless. Here, we identified the third member of the …

In Drosophila, members of the frizzled family of tissue-polarity genes encode proteins that
are likely to function as cell-surface receptors of the type known as Wnt receptors, and to …

Wingless (Wg) protein is a founding member of the Wnt family of secreted proteins which
have profound organizing roles in animal development. Two members of the Frizzled (Fz) …

The Wnt proteins constitute a large family of extracellular signalling molecules that are found
throughout the animal kingdom and are important for a wide variety of normal and …

Abstract The Frizzled (Fz) protein in Drosophila is a bifunctional receptor that acts through a
GTPase pathway in planar polarity signaling and as a receptor for Wingless (Wg) using the …

The Wnt family of secreted molecules functions in cell-fate determination and
morphogenesis during development in both vertebrates and invertebrates (reviewed in ref.) …

Members of the Frizzled family of seven-pass transmembrane proteins serve as receptors for
Wnt signalling proteins. Wnt proteins have important roles in the differentiation and …

Background Wnts are secreted proteins implicated in cell–cell interactions during
embryogenesis and tumorigenesis, but receptors involved in transducing Wnt signals have …