Telomerase is perceived as an immortality enzyme that enables passing the Hayflick limit. Its
main function is telomere restoration but only in a limited group of cells, including cancer …

Telomerase plays a pivotal role in bypassing cellular senescence and maintaining telomere
homeostasis, essential properties required for the sustenance and progression of cancer …

Telomerase has been recognized as a common factor in most tumor cells, and in turn a
distinctive feature with respect to non-malignant cells. This feature has made telomerase a …

Telomeres progressively shorten throughout life. A hallmark of advanced malignancies is
the ability for continuous cell divisions that almost universally correlates with the stabilization …

There has been a vast increase in telomerase research over the past several years, with
many different pre-clinical approaches being tested for inhibiting the activity of this enzyme …

Telomeres, the ends of chromosomes, shorten with each cell division. To expand their
replicative potential, various cell types use the ribonucleoprotein telomerase, which …

The continuous growth of advanced malignancies almost universally correlates with the
reactivation of telomerase. While there is still a great deal of basic and applied research to …

Telomerase activation is observed in almost 90% of human cancers but not in normal
tissues of somatic origin and thus is a critical step for multistep carcinogenesis. A more …

Telomerase, an enzyme that confers immortality upon cells and that is active in the majority
of human tumors, has emerged as a powerful new marker and potential prognostic indicator …

The telomere–telomerase hypothesis is the science of cellular aging (senescence) and
cancer. The ends of chromosomes, telomeres, count the number of divisions a cell can …