We identify the interfollicular (IF) zone as the site where germinal center B cell and T
follicular helper (Tfh) cell differentiation initiates. For the first 2 days postimmunization …

Germinal center (GC) B cells undergo affinity selection, which depends on interactions with
CD4+ follicular helper T cells (TFH cells). We found that TFH cells progressed through …

Higher-or lower-affinity germinal center (GC) B cells are directed either to plasma cell or GC
recycling, respectively; however, how commitment to the plasma cell fate takes place is …

Follicular helper T (Tfh) cells provide help to B cells and allow formation of long-lived
antibody responses. Despite an improved understanding of the molecular program that …

T follicular helper (Tfh) cells are defined by a Bcl6+ CXCR5 hi PD-1 hi phenotype, but only a
minor fraction of these reside in germinal centers (GCs). Here, we examined whether GC …

The discovery that Bcl-6 was the transcriptional regulator of follicular helper T (Tfh) cells
completed the recognition of this population as an effector subset specialized in the …

Germinal centers (GCs) provide a microenvironment that promotes and regulates the
interactions of B cells with follicular Th (T FH) cells. In this study, we show that there are …

Follicular helper T (Tfh) cells are necessary for germinal center (GC) formation and within
the GC, provide key signals to B cells for their differentiation into plasmablasts and plasma …

B helper follicular T (Tfh) cells are critical for long-term humoral immunity. However, it
remains unclear how these cells are recruited and contribute to secondary immune …

T follicular helper cells (Tfh cells) localize to follicles where they provide growth and
selection signals to mutated germinal center (GC) B cells, thus promoting their differentiation …