The Wnts comprise a large class of secreted proteins that control essential developmental
processes such as embryonic patterning, cell growth, migration, and differentiation. In the …

Wnt5a regulates multiple intracellular signalling cascades, but how Wnt5a determines the
specificity of these pathways is not well understood. This study examined whether the …

Wnt signaling plays a major role in regulating cell proliferation and differentiation. The Wnt
ligands are a family of 19 secreted glycoproteins that mediate their signaling effects via …

▪ Abstract Wnt genes encode a large family of secreted, cysteine-rich proteins that play key
roles as intercellular signaling molecules in development. Genetic studies in Drosophila and …

Background information. During embryonic development, β‐catenin is central both to the
transcriptional activation of Wnt [wingless‐type MMTV (murine‐mammary‐tumour virus) …

The Wnts include a large family of secreted proteins that serve as important signals during
embryonic development and adult homeostasis. In the most well understood Wnt signaling …

Abstract Background The Wnt signaling pathway regulates many processes during
embryonic development, including axis specification, organogenesis, angiogenesis, and …

In addition to activating β-catenin/TCF transcriptional complexes, Wnt proteins can elicit a
variety of other responses. These are often lumped together under the denominator …

Wnt-induced signaling via β-catenin plays crucial roles in animal development and
tumorigenesis. Both a seven-transmembrane protein in the Frizzled family and a single …

Wnt ligands are involved in diverse signaling pathways that are active during development,
maintenance of tissue homeostasis and in various disease states. While signaling regulated …