A case series of concomitant treatment of perhexiline with amiodarone

H Gilutz, MP Frenneaux… - Therapeutic drug …, 2012 - journals.lww.com
… 26 patients received this concomitant treatment without any … that concomitant treatment with
perhexiline and amiodarone may be … of plasma perhexiline concentrations to guide therapy. …

Can perhexiline be utilized without long-term toxicity? A clinical practice audit

H Phuong, BY Choi, CR Chong, B Raman… - Therapeutic drug …, 2016 - journals.lww.com
… with potentially interacting drugs (such as amiodarone, 25 … ) were not contraindications to
perhexiline therapy at entry. … details regarding concomitant CYP2D6 inhibitor therapy, this study …

Steatohepatitis-inducing drugs cause mitochondrial dysfunction and lipid peroxidation in rat hepatocytes

A Berson, V De Beco, P Lettéron, MA Robin, C Moreau… - Gastroenterology, 1998 - Elsevier
… DEAEH, amiodarone, and perhexiline augmented the … ROS.37, 38 This concomitant increase
in ROS formation may cause … or patients treated with DEAEH, amiodarone, or perhexiline. …

Therapeutic drug monitoring: antiarrhythmic drugs

TJ Campbell, KM Williams - British Journal of Clinical …, 2001 - Wiley Online Library
… TDM can be useful in the case of amiodarone to monitor … classification include digoxin and
perhexiline. TDM is very useful … substances and from other concomitantly administered drugs, …

Perhexiline and hypertrophic cardiomyopathy: a new horizon for metabolic modulation

JD Horowitz, YY Chirkov - Circulation, 2010 - Am Heart Assoc
… increased significantly by perhexiline therapy, with concomitant and marked amelioration …
case for the development of agents with less potential toxicity than amiodarone and perhexiline

[HTML][HTML] Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling

AD Balgi, BD Fonseca, E Donohue, TCF Tsang… - PloS one, 2009 - journals.plos.org
… Using an automated cell-based assay, we screened a collection of >3,500 chemicals and
identified three approved drugs (perhexiline, niclosamide, amiodarone) and one …

[HTML][HTML] Amiodarone neuropathy

S Herskovitz, LH Weimer - MedLink Neurology, 2006 - medlink.com
… In a case series of 126 patients with idiopathic bilateral … amphiphilic drugs such as perhexiline
maleate, amiodarone … enzyme system, concomitant use of amiodarone may potentiate the …

Improvement in cardiac energetics by perhexiline in heart failure due to dilated cardiomyopathy

RM Beadle, LK Williams, M Kuehl, S Bowater… - JACC: Heart Failure, 2015 - jacc.org
… Each JACC Patient Care Pathway is an immersive, multimedia case report depicting the …
than twice the upper limit of normal; concomitant use of amiodarone, quinidine, haloperidol, or …

Metabolic modulation with perhexiline in chronic heart failure: a randomized, controlled trial of short-term use of a novel treatment

L Lee, R Campbell, M Scheuermann-Freestone… - Circulation, 2005 - Am Heart Assoc
… also occur with other CPT inhibitors, such as amiodarone. The risk of developing
hepatoneurotoxicity with perhexiline is markedly reduced by monitoring and maintaining serum …

Toxic and drug-induced myopathies

MC Dalakas - Journal of Neurology, Neurosurgery & Psychiatry, 2009 - jnnp.bmj.com
Drugs that cause only neuropathy, but rarely a myopathy as monotherapy, such as ddC, ddI,
d4T, perhexiline, amiodarone, … Whether the concomitant use of steroids prevented such a …