Activation of Evi1 inhibits cell cycle progression and differentiation of hematopoietic progenitor cells
OS Kustikova, A Schwarzer, M Stahlhut, MH Brugman… - Leukemia, 2013 - nature.com
… advantage to transplanted hematopoietic cells, triggering … murine hematopoietic progenitor
cells to the activation of Evi1, … EVI1 had a biphasic effect with initial growth inhibition and …
cells to the activation of Evi1, … EVI1 had a biphasic effect with initial growth inhibition and …
Survivin modulates genes with divergent molecular functions and regulates proliferation of hematopoietic stem cells through Evi-1
S Fukuda, J Hoggatt, P Singh, M Abe, JM Speth, P Hu… - Leukemia, 2015 - nature.com
… The endogenous inhibitor of apoptosis protein Survivin … + stem and progenitor cells and
is required for cell cycle entry and … Evi1 represses PTEN expression and activates PI3K/AKT/…
is required for cell cycle entry and … Evi1 represses PTEN expression and activates PI3K/AKT/…
Evi1 is essential for hematopoietic stem cell self-renewal, and its expression marks hematopoietic cells with long-term multilineage repopulating activity
… function in hematopoietic stem/progenitor cells (HSPCs) … hypothesize Evi1 has the potential
to inhibit differentiation and … Our data indicate that Evi1 activation can function as the latter …
to inhibit differentiation and … Our data indicate that Evi1 activation can function as the latter …
[HTML][HTML] RUNX1-EVI1 disrupts lineage determination and the cell cycle by interfering with RUNX1 and EVI1 driven gene regulatory networks
SG Kellaway, P Keane, E Kennett, C Bonifer - haematologica, 2021 - ncbi.nlm.nih.gov
… progenitor cells to terminally differentiate, we induced RUNX1-… Cdkn1c encodes the cell
cycle inhibitor p57 Kip2 which is … -EVI1 target genes and an activation of the hematopoietic …
cycle inhibitor p57 Kip2 which is … -EVI1 target genes and an activation of the hematopoietic …
[HTML][HTML] The role of EVI-1 in normal hematopoiesis and myeloid malignancies
X Yuan, X Wang, K Bi, G Jiang - … journal of oncology, 2015 - spandidos-publications.com
… HSCs and hematopoietic progenitor cells. Transcriptional … EVI-1 can inhibit the AML1-induced
transcriptional activation … of the cell cycle, providing a cellular proliferative advantage …
transcriptional activation … of the cell cycle, providing a cellular proliferative advantage …
[HTML][HTML] RUNX1-Evi-1 fusion gene inhibited differentiation and apoptosis in myelopoiesis: an in vivo study
L Shen, J Zhu, F Chen, W Lin, J Cai, J Zhong, H Zhong - BMC cancer, 2015 - Springer
… that RUNX1-Evi-1 not only upregulated proteasome, cell cycle, … in hematopoietic cells than
Evi-1, it causes activation of Evi-1 … hematopoietic progenitor cells [20]. Yuasa [31] showed that …
Evi-1, it causes activation of Evi-1 … hematopoietic progenitor cells [20]. Yuasa [31] showed that …
Evi1 regulates Notch activation to induce zebrafish hematopoietic stem cell emergence
M Konantz, E Alghisi, JS Müller, A Lenard… - The EMBO …, 2016 - embopress.org
… treated with a Vegf inhibitor. In sum, our results unravel … /progenitor cells (HSPCs) that in
fish start emerging … no differences were detected in dividing or total numbers of kdrl + c‐myb + …
fish start emerging … no differences were detected in dividing or total numbers of kdrl + c‐myb + …
The role of EVI1 in myeloid malignancies
… It is likely that proviral activation of Evi1 in 32Dcl3 cells … Our unpublished data indicated
that this leads to cell cycle arrest [25]. … /progenitor cells found in murine embryonic para-aortic …
that this leads to cell cycle arrest [25]. … /progenitor cells found in murine embryonic para-aortic …
[HTML][HTML] Evi1 defines leukemia-initiating capacity and tyrosine kinase inhibitor resistance in chronic myeloid leukemia
T Sato, S Goyama, K Kataoka, R Nasu… - Oncogene, 2014 - nature.com
… composed of more differentiated progenitor cells. The relentless … (h) Cell cycle status of each
stem or progenitor fraction from … activation molecule (SLAM) markers in LSK cells of Evi1 +/…
stem or progenitor fraction from … activation molecule (SLAM) markers in LSK cells of Evi1 +/…
The Evi1 proto‐oncoprotein blocks endomitosis in megakaryocytes by inhibiting sustained cyclin‐dependent kinase 2 catalytic activity
A Kilbey, H Alzuherri, J McColl, C Calés… - British journal of …, 2005 - Wiley Online Library
… of cell cycle regulatory proteins in cultures of our panel of HEL cells to see if Evi1 mediates
… with some changes in molecular markers of differentiation observed in this study. It also …
… with some changes in molecular markers of differentiation observed in this study. It also …