… of NK1 receptor of trigeminal root ganglion via substance P paracrine mechanism contributes to the mechanical allodynia in the temporomandibular joint inflammation …

M Takeda, T Tanimoto, M Nasu, M Ikeda, J Kadoi… - Pain, 2005 - journals.lww.com
… to the activation of NK1 receptor. To determine ejection current-related effect of substance P
and an NK1 receptor … In some experiments (n=5), an NK1 receptor antagonist was used to …

[HTML][HTML] Activation of mitogen-activated protein kinases in satellite glial cells of the trigeminal ganglion contributes to substance P-mediated inflammatory pain

Y Zhang, N Song, F Liu, J Lin, M Liu, C Huang… - International journal of …, 2019 - nature.com
… neuralgia, temporomandibular joint disorders, migraine and … found that inflammatory orofacial
allodynia in rats was related … NK1 receptors are expressed in both neurons and SGCs, so …

Neuronal Cross-talk within the Trigeminal Ganglia Contributes to Inflammatory Mechanical Allodynia

M Takeda, S Matsumoto - Journal of Oral Biosciences, 2008 - Elsevier
… application of NK1 receptor antagonist(70 nA, 5 min)in inflamed rats. *… substance P
paracrine mechanism contributes to the mechanical allodynia in the temporomandibular joint

Peripheral substance P and neurokinin-1 receptors have a role in inflammatory and neuropathic orofacial pain models

FC Teodoro, MFT Júnior, AR Zampronio, AC Martini… - Neuropeptides, 2013 - Elsevier
… affect the trigeminal nerve, such as trigeminal neuralgia, invasion by tumors that compromise
joint or another orofacial structures, temporomandibular joint … Only rats that did not react to …

Peripheral and central mechanisms of mechanical allodynia: Neurokinin receptor for therapeutic target

M Takeda, S Matsumoto - Central Nervous System Agents in …, 2006 - ingentaconnect.com
… a substance P paracrine mechanism contributes to the … the temporomandibular joint (TMJ)
following TMJ inflammation. … Moreover, using the rats with the TMJ inflammation model, we …

Temporomandibular joint inflammation potentiates the excitability of trigeminal root ganglion neurons innervating the facial skin in rats

M Takeda, T Tanimoto, M Ikeda… - Journal of …, 2005 - journals.physiology.org
… of SP within the TRG via a paracrine mechanism modifies the … NK1 receptors, we used three
naïve and three inflamed rats. … substance P (SP)-immunoreactive trigeminal root ganglion (…

Peripheral and central mechanisms of trigeminal neuropathic and inflammatory pain

M Takeda, S Matsumoto, BJ Sessle, M Shinoda… - Journal of oral …, 2011 - Elsevier
… B:Peripheral inflammation upregulates NK1 receptor expression … mandibular joint inflammation
in rats:effects of substance P (… of substance P and calcitonin gene-related peptide from rat

Participation of peripheral tachykinin NK1 receptors in the carrageenan-induced inflammation of the rat temporomandibular joint

A Denadai-Souza, L de Lucca Camargo… - … Journal of Pain, 2009 - Elsevier
… release through the activation of NK1 receptors in cultured … and mechanical allodynia and
may, in turn, contribute to the … TMJ, we can conclude that peripheral substance P is not a …

Temporomandibular joint inflammation decreases the voltage-gated K+ channel subtype 1.4-immunoreactivity of trigeminal ganglion neurons in rats

M Takeda, T Tanimoto, M Nasu, S Matsumoto - European journal of pain, 2008 - Elsevier
… and this may contribute to trigeminal inflammatory allodynia in TMJ … area via a paracrine
mechanism due to the release of substance … Increased content and transport of substance P and …

[HTML][HTML] Ion channels involved in substance P-mediated nociception and antinociception

CT Chang, BY Jiang, CC Chen - International Journal of Molecular …, 2019 - mdpi.com
… effector systems underlying neurokinin 1 receptors (NK1Rs) in … in rodents produced chronic
and bilateral mechanical … sensory neurons in an autocrine or paracrine manner. In the PNS…