… identifies Kat6b as a novel regulator of hematopoietic differentiation To identify epigenetic
regulators with a functional role in hematopoietic stem and progenitor cell differentiation, we …

… Compound heterozygosity of Kat6b and the closely related gene… Kat6b alleles results in a
gene-dose-dependent reduction in the percentage of E14.5 fetal liver hematopoietic stem cells …

… Aging-associated decrease in the histone acetyltransferase KAT6B is linked to myeloid-biased
hematopoietic stem cell … Residues on histone tails can be post-translationally modified, …

… stem cells, hematopoietic stem cells, muscle satellite cells, … structure of chromatin but do not
alter gene sequences. A variety of … For example, the acetyltransferase KAT6B, found in MOZ/…

… altered with age leads to impairment in differentiation and … a better understanding of
aging-associated features and … modifiers such as KAT6B, KDM8, CBX7, and DOT1L (Fig. 2B). …

… mechanisms and functional alteration and finally may offer important clinical insights. …
underlie this aging-associated increase in the HSC number are still vague. This can be due to a …

… In addition, the histone acetyltransferase KAT6B, whose expression declines with age, is …
Knockdown of Kat6b in LT-HSCs promotes the expression of aging-associated genes [17]. …

… regulator of hematopoietic differentiation Kat6b in young LT-… proposed KAT6B as a new
target for improving age-related … results in altered clonal organization and decreased protective …

… Aging drives the genetic and epigenetic changes that result in a decline in hematopoietic
stem cell (HSC) functioning. Such changes lead to aging-related hematopoietic/immune …

… factor (MORF) or lysine acetyl transferase 6B (KAT6B) are a part of a complex that acetylate
lysine 9 … Histone deacetylase 3 modulates the expansion of human hematopoietic stem cells. …