… In contrast to their marked effect on steady-state serum digoxin levels when … , quinidine,
verapamil, and amiodarone were without effect on equilibrium binding of [ 3 H]digoxin. Thus, …

… , verapamil and diltiazem) can further … digoxin and quinidine for a long time before we
appreciated their interaction. Dr. Scheinman: Is the effect of amiodarone caused by protein binding…

… verapamil, digoxin, and amiodarone. In this review, Pgp-mediated DDIs and their effects
on … renal clearance of quinidine at elevated doses, although digoxin’s effect on the AUC of …

… Blood samples were collected to determine plasma edoxaban concentrations at serial time
points over 24 h (quinidine, digoxin, and verapamil) or 72 h (amiodarone, atorvastatin, and …

… telmisartan and verapamil, respectively. For telmisartan and verapamil, variability was greatly
… brings the range in IC 50 values for telmisartan and verapamil down to 69- and 159-fold. …

… Digoxin verapamil and quinidine are substrates of P-glycoprotein and verapamil and quinidine
inhibit the clearance of digoxin … amiodarone combined with digoxin increases the digoxin …

… pharmacokinetic interaction of digoxin with quinidine has been … of digoxin with amiodarone
and with verapamil has been … of digoxin after quinidine was higher than when digoxin was …

… established that quinidine increased plasma digoxin concentration by … , when amiodarone
is given to a patient taking oral digoxin, … reducing the dose of digoxin when starting verapamil. …

… verapamil inhibits the biliary and renal elimination of digoxin. … digoxin be measured in
patients currently taking digoxin before treatment with quinidine, amiodarone, or itraconazole is …

… is that quinidine displaces digoxin from its binding sites in skeletal (and perhaps cardiac)
muscle, although this explanation is not … drugs that increase digoxin serum levels (amiodarone; …