[HTML][HTML] Antibody targeting of E3 ubiquitin ligases for receptor degradation
… degradation. Notably, by examining a matrix of additional cell-surface E3 ubiquitin ligases and
transmembrane receptors, … for ‘on-demand’ degradation. Furthermore, we offer insights on …
transmembrane receptors, … for ‘on-demand’ degradation. Furthermore, we offer insights on …
Receptor elimination by E3 ubiquitin ligase recruitment (REULR): a targeted protein degradation toolbox
… (ICIs) such as antibodies targeting CTLA-4 (ipilimumab), … Targeted protein degradation
could provide a major expansion in the repertoire of modulating immune checkpoint receptors by …
could provide a major expansion in the repertoire of modulating immune checkpoint receptors by …
Engineering a single ubiquitin ligase for the selective degradation of all activated ErbB receptor tyrosine kinases
F Kong, J Zhang, Y Li, X Hao, X Ren, H Li, P Zhou - Oncogene, 2014 - nature.com
… antibody against the extracellular domain of the receptor. As … low levels of chimeric E3 ligase
expression (indicated by low … Thus, we next examined whether the targeted degradation of …
expression (indicated by low … Thus, we next examined whether the targeted degradation of …
Targeting E3 ubiquitin ligases for cancer therapy
Y Sun - Cancer biology & therapy, 2003 - Taylor & Francis
… or GPCR (G ProteinCoupled Receptor) or a cell surface … small molecular inhibitors or targeted
by specific antibodies; and 5. … as an E3 ubiquitin ligase to promote rapid degradation of p53…
by specific antibodies; and 5. … as an E3 ubiquitin ligase to promote rapid degradation of p53…
[PDF][PDF] The CUL7 E3 ubiquitin ligase targets insulin receptor substrate 1 for ubiquitin-dependent degradation
… targeted degradation of IRS-1 by the CUL7 E3 ligase constitutes a core component of the
mTOR negative-feedback loop. This E3 … antibody, and sources for other antibodies as well as …
mTOR negative-feedback loop. This E3 … antibody, and sources for other antibodies as well as …
[PDF][PDF] Expanding the arsenal of E3 ubiquitin ligases for proximity-induced protein degradation
A Kannt, I Đikić - Cell chemical biology, 2021 - cell.com
… targeted protein degradation are DCAF15, DCAF16, and the arylhydrocarbon receptor (AhR)
E3 ligase… Thus, even though PD-L1 degradation was independent of the UPS, this antibody-…
E3 ligase… Thus, even though PD-L1 degradation was independent of the UPS, this antibody-…
Targeted protein degradation: expanding the toolbox
M Schapira, MF Calabrese, AN Bullock… - Nature reviews Drug …, 2019 - nature.com
… E3 ubiquitin ligases have so far been exploited for targeted … such as monoclonal antibodies
and oligonucleotide therapies … receptors, leading to degradation of their respective targets 2,…
and oligonucleotide therapies … receptors, leading to degradation of their respective targets 2,…
[PDF][PDF] Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGFβ receptor for degradation
… an antibody that recognizes Smurf2 bound to the receptors. … This mechwe report on a
novel ubiquitin ligase we call … TGF receptors and is likely critical to target the TGF receptor for …
novel ubiquitin ligase we call … TGF receptors and is likely critical to target the TGF receptor for …
Advancing targeted protein degradation for cancer therapy
… E3 ubiquitin ligase and a target protein, leading to polyubiquitination and degradation of the
… and pomalidomide, which bind a substrate receptor of the E3 ligase cereblon (CRBN) 25 , …
… and pomalidomide, which bind a substrate receptor of the E3 ligase cereblon (CRBN) 25 , …
[HTML][HTML] Calcium-sensing receptor ubiquitination and degradation mediated by the E3 ubiquitin ligase dorfin
Y Huang, J Niwa, G Sobue, GE Breitwieser - Journal of biological chemistry, 2006 - ASBMB
… Final transfer of activated ubiquitin to target proteins is coordinated by the E3 ligase, which
… antibody. The Western blot was probed with anti-HA antibody to detect ubiquitinated species. …
… antibody. The Western blot was probed with anti-HA antibody to detect ubiquitinated species. …