Assessment of solid microneedle rollers to enhance transmembrane delivery of doxycycline and inhibition of MMP activity
A Omolu, M Bailly, RM Day - Drug delivery, 2017 - Taylor & Francis
… of an epidermal mimetic with microneedle rollers provides sufficient permeabilization for
doxycycline diffusion and inhibition of MMP activity. We conclude that microneedle rollers are a …
doxycycline diffusion and inhibition of MMP activity. We conclude that microneedle rollers are a …
[HTML][HTML] Matrix metalloproteinases: The sculptors of chronic cutaneous wounds
VR Krishnaswamy, D Mintz, I Sagi - Biochimica et Biophysica Acta (BBA) …, 2017 - Elsevier
… non-ECM components like transmembrane proteins, cell surface … On the other hand, MMP-2
which degrades laminin-332 to promote … Doxycycline and Minocycline are two well-known …
which degrades laminin-332 to promote … Doxycycline and Minocycline are two well-known …
Microneedles-based transdermal drug delivery systems: a review
Y Hao, W Li, XL Zhou, F Yang… - Journal of biomedical …, 2017 - ingentaconnect.com
… The solid microneedle roller enhanced the transmembrane delivery of doxycycline and
inhibition of MMP activity.Kalluri … could be an attractive application in blood analysis systems.The …
inhibition of MMP activity.Kalluri … could be an attractive application in blood analysis systems.The …
[HTML][HTML] Microneedles for enhanced topical treatment of skin disorders: applications, challenges, and prospects
T Peng, Y Chen, W Hu, Y Huang, M Zhang, C Lu… - Engineering, 2023 - Elsevier
… The qualitative and quantitative evaluation of MNs can help … membrane-inspired biomineralized
NPs that were delivered … responses and exerted a better tumor inhibitory effect. The DNA …
NPs that were delivered … responses and exerted a better tumor inhibitory effect. The DNA …
Microneedles as an alternative technology for transdermal drug delivery systems: a patent review
MLB Queiroz, S Shanmugam, LNS Santos… - Expert opinion on …, 2020 - Taylor & Francis
… bioactives and enhance transdermal and dermal delivery. So… the uniformity control membrane
is substantially greater than … from the skin for analysis such as analysis of blood sugar for …
is substantially greater than … from the skin for analysis such as analysis of blood sugar for …
Brain targeted oral delivery of doxycycline hydrochloride encapsulated Tween 80 coated chitosan nanoparticles against ketamine induced psychosis: behavioral …
… of pure doxycycline hydrochloride, showing better penetration of … , followed by evaluation of
their antipsychotic activity in … ) and placed in a dialysis membrane bag (molecular weight cut …
their antipsychotic activity in … ) and placed in a dialysis membrane bag (molecular weight cut …
Zein-maltodextrin nanocomplex based dissolving microneedle: A promising approach for Paliperidone palmitate delivery
VY Londhe, RS Bhadale - International Journal of Biological …, 2023 - Elsevier
… Microneedling enhanced the concentration of PLDN in … to replicate human skin in order to
assess whether or not MNs are … M® membrane, a synthetic, non-animal membrane that can be …
assess whether or not MNs are … M® membrane, a synthetic, non-animal membrane that can be …
Microneedles: structure, classification, and application in oral cancer theranostics
X Li, X Xie, Y Wu, Z Zhang, J Liao - … Delivery and Translational Research, 2023 - Springer
… MNs improve the efficiency of drug delivery in a painless … to penetrate the oral mucous
membrane to deliver drugs. The … of tumors in mice with a good inhibitory effect [55]. However, …
membrane to deliver drugs. The … of tumors in mice with a good inhibitory effect [55]. However, …
[HTML][HTML] Physical drug delivery enhancement for aged skin, UV damaged skin and skin cancer: Translation and commercialization
… Delivery was assessed in thawed porcine skin from the … show that microneedles can enhance
the delivery of small … enhancement may have been inhibited by the hydrophobic properties …
the delivery of small … enhancement may have been inhibited by the hydrophobic properties …
Differential effects of doxycycline, a broad-spectrum matrix metalloproteinase inhibitor, on angiotensin II–induced atherosclerosis and abdominal aortic aneurysms
MW Manning, LA Cassis… - … , thrombosis, and vascular …, 2003 - Am Heart Assoc
… The abdominal aorta was excluded from analysis owing to the presence of … MMP activity in
atherosclerotic lesions is enhanced, particularly at shoulder regions. Although MMP activity is …
atherosclerotic lesions is enhanced, particularly at shoulder regions. Although MMP activity is …