Attacking heterogeneity in schizophrenia by deriving clinical subgroups from widely available symptom data

D Dickinson, DN Pratt, EJ Giangrande… - Schizophrenia …, 2018 - academic.oup.com
… of schizophrenia might emerge from data-driven analyses of negative and distress symptom
… the 2 PANSS dimensions were analyzed in the full schizophrenia sample using the 2-step …

Improving individual predictions: machine learning approaches for detecting and attacking heterogeneity in schizophrenia (and other psychiatric diseases)

HG Schnack - Schizophrenia research, 2019 - Elsevier
… with factor analysis of clinical (CASH) data to obtain a split of … related to symptom profiles,
since clinical heterogeneity is reduced … into two schizophrenia subgroups was found. After this …

Subtyping schizophrenia based on symptomatology and cognition using a data driven approach

LFS Castro-de-Araujo, DB Machado, ML Barreto… - Psychiatry Research …, 2020 - Elsevier
Schizophrenia is a highly heterogeneoussymptom severity in addition. We believe that
k-means clustering, which is neutral to the type of indicator used, may help identify subgroups

Subtyping schizophrenia patients based on patterns of structural brain alterations

Y Xiao, W Liao, Z Long, B Tao, Q Zhao… - Schizophrenia …, 2022 - academic.oup.com
Schizophrenia syndrome is a clinically heterogeneous and … for differences in clinical
features in identified subgroups. We … Here, analyzing structural neuroimaging data with a novel …

[HTML][HTML] Neurobiological divergence of the positive and negative schizophrenia subtypes identified on a new factor structure of psychopathology using non-negative …

J Chen, KR Patil, S Weis, K Sim, T Nickl-Jockschat… - Biological …, 2020 - Elsevier
data, this work further disentangles the heterogeneity in … analyzed in the same dataset
used to derive the dictionary. … Fuzzy c-means clustering results of patient subgroups based …

Heterogeneity of emotional experience in schizophrenia: Trait affect profiles predict clinical presentation and functional outcome.

HR Cowan, VA Mittal, DN Allen, JM Gold… - Journal of abnormal …, 2020 - psycnet.apa.org
… , and whether those subgroups differed in their symptom presentation and … heterogeneity
of trait emotional experience through a data-driven analysis of affective traits subgroups

Characterizing speech heterogeneity in schizophrenia-spectrum disorders.

PP Oomen, JN de Boer, SG Brederoo… - … and clinical science, 2022 - psycnet.apa.org
… of SSD, speech markers are an unexplored source of symptom heterogeneity … A data-driven
hierarchical clustering approach indicated the presence of three diverse speech subgroups

Symptom dimensions and subgroups in childhood-onset schizophrenia

KES Craddock, X Zhou, S Liu, P Gochman… - Schizophrenia …, 2018 - Elsevier
… broad themes of subgroups, often deriving a “deficit” or severe negative … the heterogeneity
of schizophrenia and may reveal … Data from 125 COS patients were used in this study (Table 1)…

Cortical morphological heterogeneity of schizophrenia and its relationship with glutamatergic receptor variations

X Ouyang, Y Pan, X Chen, G Wu, Y Cheng… - European …, 2023 - cambridge.org
… ’ subgroups of patients, with higher negative symptom burden and … to observe using functioning
data from follow-up assessments. … Attacking Heterogeneity in Schizophrenia by Deriving

Cortical impoverishment in a stable subgroup of schizophrenia: Validation across various stages of psychosis

L Liang, RW Heinrichs, PF Liddle, P Jeon… - Schizophrenia …, 2022 - Elsevier
Deriving neurobiological subgroups without considering … Data used in the present study
were obtained from three … In our investigation of the heterogeneity of schizophrenia, the cluster …