Autophagic cell death induced by resveratrol depends on the Ca2+/AMPK/mTOR pathway in A549 cells

J Zhang, JF Chiu, H Zhang, T Qi, Q Tang, K Ma… - Biochemical …, 2013 - Elsevier
… compound C, and the calcium ion-chelating agent EGTA. … resveratrol-induced A549 cell
death was mediated by the process of autophagic cell death via Ca 2+ /AMPK-mTOR signaling

Resveratrol induces autophagy and apoptosis in non-small-cell lung cancer cells by activating the NGFR-AMPK-mTOR pathway

J Li, Y Fan, Y Zhang, Y Liu, Y Yu, M Ma - Nutrients, 2022 - mdpi.com
… on autophagy and apoptosis induced by RSV in A549 cells … the cell survival rate in time-
and concentration-dependent … roles of autophagy and apoptosis in cancer cell death and the …

Resveratrol, an activator of SIRT1, induces protective autophagy in non-small-cell lung cancer via inhibiting Akt/mTOR and activating p38-MAPK

J Wang, J Li, N Cao, Z Li, J Han, L Li - OncoTargets and therapy, 2018 - Taylor & Francis
… and H1299 cells in a dose-dependent manner compared with … resveratrol-induced autophagy
through treating A549 cell … and excessive autophagy could lead to autophagic cell death. …

Resveratrol modulates the apoptosis and autophagic death of human lung adenocarcinoma A549 cells via a p53‑dependent pathway: Integrated bioinformatics …

Y Fan, J Li, Y Yang, X Zhao, Y Liu… - International …, 2020 - spandidos-publications.com
… upstream signal, such as the AMPK/mTOR signaling pathway, PI3K/Akt/mTOR signaling
its anti-tumor effects in A549 cells by inducing apoptosis and autophagic cell death via the p53 …

… , 4, 5, 4′-trans-tetramethoxystilbene, a new analogue of resveratrol, inhibits gefitinb-resistant non-small cell lung cancer via selectively elevating intracellular calcium …

XX Fan, XJ Yao, SW Xu, VKW Wong, JX He, J Ding… - Scientific reports, 2015 - nature.com
… activation of calcium signaling would lead to cell death. As … as well as autophagy in GR
NSCLC cells, providing strategy … -AMPK- mTOR pathway. Noted that the main members of this …

Targeting akt/mtor and bcl-2 for autophagic and apoptosis cell death in lung cancer: novel activity of a polyphenol compound

S Tungsukruthai, O Reamtong, S Roytrakul, S Sukrong… - Antioxidants, 2021 - mdpi.com
… found that resveratrol induced the apoptosis and ACD in A549 cells via a p53-dependent
pathway [64]… Moreover, ACD induced by resveratrol depends on the Ca 2+ /AMPK/mTOR

Targeting of cancer cell death mechanisms by resveratrol: a review

X Fu, M Li, C Tang, Z Huang, M Najafi - Apoptosis, 2021 - Springer
… that stimulation of autophagy cell death may be useful for … -small cell lung cancer cells (A549)
with resveratrol has been … a time-dependent property for the type of cell death that can …

Resveratrol as a natural regulator of autophagy for prevention and treatment of cancer

Y Tian, W Song, D Li, L Cai, Y Zhao - OncoTargets and therapy, 2019 - Taylor & Francis
… can induce cell death by itself or initiate apoptosis. Citation30 … Citation2 +/AMPK-mTOR
signaling pathway, and treatment … that resveratrol has the ability to induce mTOR-dependent

Resveratrol induces autophagy-dependent apoptosis in HL-60 cells

Y Fan, JF Chiu, J Liu, Y Deng, C Xu, J Zhang, G Li - BMC cancer, 2018 - Springer
… RSV-induced HL-60 cell death involves autophagy-dependent … of AMPK-mTOR pathway is
involved in RSV-induced … are enhanced by RSV, similar to our prior publication on A549 cells […

Modulation of autophagy in cancer cells by dietary polyphenols

C Musial, K Siedlecka-Kroplewska, Z Kmiec… - Antioxidants, 2021 - mdpi.com
… viability of A549 cells and it was found that resveratrol decreased … to induce autophagic cell
death in A549 human lung adenocarcinoma cells via Ca 2+ /AMPK-mTOR signaling pathway