… will provide a specific view of our group on the structural and functional neural mechanisms
underlying emotional and motivational dysregulation in bipolar disorder based on our own …

… to disturbed emotion and motivation processing in bipolar disorder are more likely to evolve
during the course of the disease or rather constitute a vulnerability factor for bipolar disorder. …

… neural network functional connectivity (1) has motivated their employment toward the study
of neural networks … , as a potential neural mechanism underlying emotional lability and mood …

… the motivation for the refinement of our original neural model, specifically to expand upon …
part of the neural network recruited to support this voluntary emotion regulatory subprocess. …

… We shall apply neural network theory in an effort to ascertain the nature of their modulatory
functions. But first we need to review the relevant neurobiological facts that severely constrain …

… Patients with Bipolar disorder experience high mood swings that include excessive highs
(… While they feel opposite during depressive episodes with a strong feeling of hopeless and …

… Although many researchers tend to focus on positive stimuli, we believe that approach… like
disparate mood states, consider the example of a person who is highly motivated to achieve a …

… Fluctuations in mood, affect, and motivation are a cornerstone … Contemporary neurobiological
theories of emotion posit a … -limbic neural circuits underlies the emotional and cognitive …

… ) (inhibitory control processes common to voluntary emotion-regulation subprocesses) have
motivated a focus on the ventrolateral prefrontal cortex in particular in research on voluntary …

… -related limbic activity, but also an excitatory effect on other prefrontal neural networks. This
… mood states of bipolar disorder as well as of unipolar depression are associated with a mood…