… the effects of a pharmacological Rho inhibitor, C3 bot , on axonal outgrowth and regeneration
in ex vivo models of motor and sensory neuron regeneration as well as in the sciatic nerve …

… activity of C3, in fact, is not essential for axonal and dendritic growth … -specific uptake of C3,
in fact, reflects our lack of knowledge. … C3 bot has been shown in different in vitro and in vivo …

… C3-ADP ribosyltransferase is a 24-kDa exoenzyme … to the lack of significant RGC regeneration
after optic nerve injury. Another … axon regeneration in vivo, we studied the effect of C3 on …

… We first investigated the in vivo effects of the 29-amino-acid … Thus, despite the lack of
enzymatic activity, the C3 peptide is … not denervated by peripheral nerve lesion but experienced …

… to CSPG substrates in in vitro stripe assays. Silver and … the Clostridium botulinum exoenzyme
C3 transferase, which … The lack of a combinatorial effect of PTEN and Nogo deletion on …

… C3 bot transferase, an exoenzyme produced by Clostridium … show that the C3 bot mutant,
C3 E174Q , which lacks RhoA … counteracted the axonotrophic effects we observed in vitro in a …

… the full coding sequence of C3 exoenzyme (GenBank: CAA35828.1 … growth in vitro and
axonal regeneration following injury, we … 154–182) lacking the domain responsible for enzymatic …

… In this study, the effect of different constructs of C3 on SGN alone and … The action of different
constructs of C3 on SGN in vitro have … Despite the lack of a receptor-binding domain, several …

… their inhibitory effects on axon regeneration. However, CNS … the DRG lack dendrites
and are pseudo-unipolar with a peripheral … In vivo imaging studies have shown that pre-conditioning …

… , allowed axons to grow on myelin both in culture 9 and in vivo … C3, Clostridium botulinum
C3 exoenzyme; NT, neurotrophin; … C3 is delivered intrathecally, it has no effect on regeneration …