… metabolic activation of ABP.9, 10 In the present study, we found that CYP2A13 is highly
expressed in bladder … N-hydroxylated by human bladder microsomes or recombinant CYP2A13. …

… ), perhaps due to their metabolism in RT4 cells. Therefore, … CYP2A13 expressed in the
bladder efficiently bioactivates 4-ABP to form DNA adducts. These data are consistent with human …

… , as well as in a mouse hepatoma cell line transiently expressing recombinant mouse
CYP1A2 or CYP2E1. We have also measured the in vivo plasma clearance of ABP in adult wild-…

… Recently, it was found that CYP2A13 could catalyze the metabolic activations of 4-aminobiphenyl …
Because CYP2A13 is highly expressed in the human respiratory tract, we determined …

… , the bulk of this review focuses on NAT-mediated metabolism. NATs serve as a line of defense
by … For instance, dogs lack NAT expression in either liver or bladder, yet are still prone to …

… given that most chemical carcinogens require metabolic … "metabolic activation" reactions,
whereas metabolic reactions … NAT2 polymorphisms to human bladder cancer. Historically it was …

… Because CYP2A13 is highly active in the metabolic activation of several carcinogens, it was
… CYP2A13, which is expressed in human bladder, metabolically activates aminobiyphenol […

… CYP2A13 and CYP2A6 enzymes but at different rates. Phenacetin and 4-aminobiphenyl
were identified as substrates of human … in expressing and purifying some of the CYP2A13 …

… CYP2A13 protein in human lung microsomes and to ascertain whether CYP2A13 plays any
role in lung microsomal NNK metabolic … for human bladder microsomes, in which CYP2A13 …

… for bladder cancer [17,44], the appropriate inhibition … CYP2A13 might stop the metabolism
of some aromatic amines from smoke (eg, 4-aminobiphenyl) that is metabolized by CYP2A13 …