Cannabinoid receptor type 1 antagonist, AM251, attenuates mechanical allodynia and thermal hyperalgesia after burn injury

M Ueda, H Iwasaki, S Wang, E Murata, KYT Poon… - …, 2014 - pubs.asahq.org
burn injury activates glial cells, and cannabinoid receptor 1 (CB1R) antagonist, AM251, will
decrease burn … using rat hind paw burn injury model of thermal hyperalgesia and mechanical

Activation of peripheral cannabinoid receptors attenuates cutaneous hyperalgesia produced by a heat injury

LM Johanek, DA Simone - Pain, 2004 - journals.lww.com
CB1 receptor was implicated since the antihyperalgesic effects were attenuated by the CB1
selective antagonist AM 251One of the advantages of using the capsaicin and burn injury

… effect of arachidonylcyclopropylamide, a cannabinoid 1 receptor agonist & lignocaine, a local anaesthetic agent, following direct intrawound administration in rats

R Kumar, P Prasoon, M Gautam… - Indian Journal of Medical …, 2016 - journals.lww.com
… antinociceptive effect of type 1 cannabinoid receptor (CB1r) … AM251 alone significantly
reversed thermal hyperalgesiaattenuated thermal hyperalgesia and mechanical allodynia. It may …

TARGETING THE ENDOCANNABINOID SYSTEM WITH ORTHOSTERIC AND ALLOSTERIC CANNABINOID LIGANDS TO REDUCE CORNEAL PAIN AND …

D Thapa - 2019 - dalspace.library.dal.ca
… orthosteric and allosteric cannabinoid receptor ligands using … can reduce the expression of
c-Fos leading to attenuation of c… (AM251) or 5-HT1A receptor (WAY100635) antagonists were …

Inhibition of Inflammatory Hyperalgesia by Activation of Peripheral CB2Cannabinoid Receptors

A Quartilho, HP Mata, MM Ibrahim… - The Journal of the …, 2003 - pubs.asahq.org
… by using the CB2 receptor-selective antagonist AM630 and the CB1 receptor-selective …
of the CB 1 receptor–selective antagonist AM251 alone did not result in hyperalgesia. This …

Cannabinoid 1 receptor knockout mice display cold allodynia, but enhanced recovery from spared-nerve injury-induced mechanical hypersensitivity

A Sideris, B Piskoun, L Russo, M Norcini… - Molecular …, 2016 - journals.sagepub.com
… an antagonist of CB1R administered systemically significantly reduces mechanical and
thermal hyperalgesia … pain relief and recovery after peripheral nerve and burn injuries, 16–18 …

Cannabinoid modulation of nociception and nociceptor activity during inflammation.

CR Potenzieri - 2009 - conservancy.umn.edu
Attenuation of heat hyperalgesia by ACEA through activation … receptor potential vanilloid
type one (TRPV1) receptors. … CB1 receptor antagonist AM251 or CB2 receptor antagonist

Resolvin D1 attenuates mechanical allodynia after burn injury: Involvement of spinal glia, p38 mitogen-activated protein kinase, and brain-derived neurotrophic factor …

X Zhao, X Li, H Guo, P Liu, M Ma, Y Wang - Molecular Pain, 2023 - journals.sagepub.com
… downregulated BDNF/TrkB following burn injury. Furthermore, … might attenuate mechanical
allodynia after burn injury by … that burn injury in rats resulted in hyperalgesia and allodynia

Cannabinoid modulation of cutaneous Aδ nociceptors during inflammation

C Potenzieri, TS Brink… - Journal of …, 2008 - journals.physiology.org
… of the cannabinoid receptor agonists, methAEA or ACEA, … alter mechanical allodynia or
hyperalgesia after inflammation … 1 receptor antagonist AM251 attenuated both the decrease in …

Nonopioid GTS-21 mitigates burn injury pain in rats by decreasing spinal cord inflammatory responses

Y Zhou, Y Leung-Pitt, H Deng, Y Ren, Z You… - Anesthesia & …, 2021 - journals.lww.com
… MLA is a specific α7AChR blocker for 1 wk. Preliminary … GTS-21 attenuates postburn
mechanical allodynia in young … GTS-21 attenuated postburn heat hyperalgesia in young rats. A, …