… investigated in humans. In this work, we examine the changes in mRNA expression induced
… in vivo, as a model of emergency granulopoiesis in humans. Blood samples were collected …

… elucidated in humans. Here, we investigate the changes in mRNA and miRNA expression in
… of G-CSF in humans, mimicking emergency granulopoiesis. Blood samples were collected …

… (G) Representative FACS profile showing characteristic G-CSF–induced changes in BM …
, we injected Myd88 fl/fl and Tie2-Cre;Myd88 fl/fl mice with recombinant human G-CSF (Figure …

… , multiple studies in mice and humans have shown highly upregulated … G-CSF-induced
signal transduction occurs via Janus kinase (JAK)–signal transducer and activator of transcription …

… -response proteins that directly regulate gene expression. Evidence linking either STAT1 or
… acute mobilization response while minimizing the contribution of G-CSF–induced nascent …

… G-CSF induced emergency granulopoiesis in humans … The gene expression profile also
revealed activation of the TLR … While there were changes in the proliferation and survival …

… is mediated by G-CSF-induced emergency granulopoiesis (60). … a myeloid gene expression
program through interacting … from preclinical studies into human infectious and hematologic …

… The study revealed that T cells express G-CSFR, and its interaction with G-CSF induced a
Th2 phenotype through GATA-3. This finding supports G-CSF as a strong immune regulator of …

… -deficient granulocytes on G-CSF–induced maturation. In wild… human granulopoiesis. In
comparison, STAT3-deficient … We examined C/EBPβ protein and mRNA expression in wild-type …

… dent gene expression after stimulation of the cell with … the regulation of G-CSF-induced
cellular responses in vivo, … to defects or changes in differentiation, cell cycle, or survival. cient …