… of cholesterol metabolism that also modulate immune responses. … cholesterol metabolism
contributes to autoimmunity is unclear. Here we found that cholesterol loading of CD11c+ cells …

… HDL mediates cholesterol efflux from immune cells via ATP … have a causal relationship to
autoimmune diseases is … CD11b+ cells, >50% of which show expression of CD11c and MHCII (…

… may serve as an important regulator of immune cell activity … and binding of the virulence
factor cytolethal distending toxin (… Western diet feeding increased cholesterol accumulation in …

… and immune disorders including autoimmune diseases, cancers… Cholesterol buildup in CD11c
+ MHCII + cells impairs antigen … cholesterol metabolism and the adaptive immune system. …

… functions and how cholesterol accumulation impacts chronic … that high plasma cholesterol
levels are a causal risk factor for … Of note, although autoimmune diseases, such as rheumatoid …

… Autoimmune disorders typically show enlargement of … population (A) and for the CD11c
− population (D). Results … we speculate that cholesterol accumulates in skin draining LNs …

… innate immune cells including macrophages and dendritic cells … Autoimmune diseases are
caused by the loss of immune tolerance … Cholesterol accumulation in dendritic cells, not in …

… lipid rafts to relavant targeted organs (113). … cholesterol-containing diet in ApoE/LXRβ-deficient
mice would result in lupus-like disease, and defects of LXRβ in CD11c+cells led to B-cell …

… This includes a role in the immune system, in which HDL has … To exclude a possible role of
reverse causation, we … that cholesterol accumulation in cells can affect the immune function (5…

… to accumulate in WAT in obesity and are the dominant CD11c + … as at least a partial causal
agent as ovariectomized monkeys … in this cholesterol lowering effect of CD11c + cells, likely …