Choosing appropriate solvents for ASD preparation
C Luebbert, D Real, G Sadowski - Molecular pharmaceutics, 2018 - ACS Publications
… Preparation of ASDs The ASDs investigated in this work were prepared by solvent evaporation.
In total, 500 mg of API and polymer were weighted in the desired API/polymer ratio on an …
In total, 500 mg of API and polymer were weighted in the desired API/polymer ratio on an …
Amorphous solid dispersion of nisoldipine by solvent evaporation technique: Preparation, characterization, in vitro, in vivo evaluation, and scale up feasibility study
RB Chavan, A Lodagekar, B Yadav… - Drug delivery and …, 2020 - Springer
… Also, ASD preparation from lab scale formulation technique … ASDs of nisoldipine were
prepared using rotary evaporation (… for selection of appropriate polymer in development of ASDs …
prepared using rotary evaporation (… for selection of appropriate polymer in development of ASDs …
Amorphous solid dispersions of BCS class II drugs: a rational approach to solvent and polymer selection
… upon a miniaturised solvent casting (MSC) method as a predictive tool for ASD stability.
In … the effect of legacy solvents on the stability of ASD made by solvent-casting. Consider …
In … the effect of legacy solvents on the stability of ASD made by solvent-casting. Consider …
Solvent influence on manufacturability, phase behavior and morphology of amorphous solid dispersions prepared via bead coating
E Boel, F Giacomini, G Van den Mooter - European Journal of …, 2021 - Elsevier
… The importance of solvent selection for ASD manufacturing … auspicious alternative
solvent-based ASD preparation method … influence of the solvent on ASDs prepared with bead …
solvent-based ASD preparation method … influence of the solvent on ASDs prepared with bead …
Amorphous solid dispersions: utilization and challenges in drug discovery and development
Y He, C Ho - Journal of pharmaceutical sciences, 2015 - Elsevier
… solvents is often unavoidable and this raised issues with potential for residual solvents in the
ASD… Nevertheless, SD is usually the technique of choice to prepare ASD in discovery when …
ASD… Nevertheless, SD is usually the technique of choice to prepare ASD in discovery when …
Solvent-casted films to assist polymer selection for amorphous solid dispersions during preclinical studies: In-vitro and In-vivo Exploration
LI Mosquera-Giraldo, M Donoso, K Stefanski… - Pharmaceutical …, 2021 - Springer
… In the past, we used HPMCAS-MG as the default polymer to prepare ASDs for discovery
studies. This decision was based on the fact that HPMCAS-MG appeared to provide stable …
studies. This decision was based on the fact that HPMCAS-MG appeared to provide stable …
[HTML][HTML] Solvent influence on the phase behavior and glass transition of Amorphous Solid Dispersions
S Dohrn, C Luebbert, K Lehmkemper… - European Journal of …, 2021 - Elsevier
… Thus, the presented methodology allows for an in-silico selection of appropriate solvent
systems for solvent-based ASD preparation based on a limited amount of experimental data for …
systems for solvent-based ASD preparation based on a limited amount of experimental data for …
Phase behavior of pharmaceutically relevant polymer/solvent mixtures
S Dohrn, C Luebbert, K Lehmkemper… - International Journal of …, 2020 - Elsevier
… However, the selection of inappropiate solvents can lead to … to be appropriate solvents for
preparing ASDs based on … found to be appropriate solvents for ASD preparation using PVP K90…
preparing ASDs based on … found to be appropriate solvents for ASD preparation using PVP K90…
[HTML][HTML] Pharmaceutical amorphous solid dispersion: A review of manufacturing strategies
SV Bhujbal, B Mitra, U Jain, Y Gong, A Agrawal… - … Pharmaceutica Sinica B, 2021 - Elsevier
… techniques for preparing ASDs. As physical stability is a critical quality attribute for ASD, the
… Selection strategies are proposed to identify suitable manufacturing methods, which may …
… Selection strategies are proposed to identify suitable manufacturing methods, which may …
Thermodynamic modeling of solvent-impact on phase separation in amorphous solid dispersions during drying
S Dohrn, P Reimer, C Luebbert… - Molecular …, 2020 - ACS Publications
… /water system showed the predicted liquid–liquid phase separation during drying and is
thus regarded as an inappropriate solvent choice for HPMCAS-based ASD preparation by …
thus regarded as an inappropriate solvent choice for HPMCAS-based ASD preparation by …