Choosing appropriate solvents for ASD preparation

C Luebbert, D Real, G Sadowski - Molecular pharmaceutics, 2018 - ACS Publications
Preparation of ASDs The ASDs investigated in this work were prepared by solvent evaporation.
In total, 500 mg of API and polymer were weighted in the desired API/polymer ratio on an …

Amorphous solid dispersion of nisoldipine by solvent evaporation technique: Preparation, characterization, in vitro, in vivo evaluation, and scale up feasibility study

RB Chavan, A Lodagekar, B Yadav… - Drug delivery and …, 2020 - Springer
… Also, ASD preparation from lab scale formulation technique … ASDs of nisoldipine were
prepared using rotary evaporation (… for selection of appropriate polymer in development of ASDs

Amorphous solid dispersions of BCS class II drugs: a rational approach to solvent and polymer selection

MT Davis, DP Egan, M Kuhs, AB Albadarin… - … Research and Design, 2016 - Elsevier
… upon a miniaturised solvent casting (MSC) method as a predictive tool for ASD stability.
In … the effect of legacy solvents on the stability of ASD made by solvent-casting. Consider …

Solvent influence on manufacturability, phase behavior and morphology of amorphous solid dispersions prepared via bead coating

E Boel, F Giacomini, G Van den Mooter - European Journal of …, 2021 - Elsevier
… The importance of solvent selection for ASD manufacturing … auspicious alternative
solvent-based ASD preparation method … influence of the solvent on ASDs prepared with bead …

Amorphous solid dispersions: utilization and challenges in drug discovery and development

Y He, C Ho - Journal of pharmaceutical sciences, 2015 - Elsevier
solvents is often unavoidable and this raised issues with potential for residual solvents in the
ASD… Nevertheless, SD is usually the technique of choice to prepare ASD in discovery when …

Solvent-casted films to assist polymer selection for amorphous solid dispersions during preclinical studies: In-vitro and In-vivo Exploration

LI Mosquera-Giraldo, M Donoso, K Stefanski… - Pharmaceutical …, 2021 - Springer
… In the past, we used HPMCAS-MG as the default polymer to prepare ASDs for discovery
studies. This decision was based on the fact that HPMCAS-MG appeared to provide stable …

[HTML][HTML] Solvent influence on the phase behavior and glass transition of Amorphous Solid Dispersions

S Dohrn, C Luebbert, K Lehmkemper… - European Journal of …, 2021 - Elsevier
… Thus, the presented methodology allows for an in-silico selection of appropriate solvent
systems for solvent-based ASD preparation based on a limited amount of experimental data for …

Phase behavior of pharmaceutically relevant polymer/solvent mixtures

S Dohrn, C Luebbert, K Lehmkemper… - International Journal of …, 2020 - Elsevier
… However, the selection of inappropiate solvents can lead to … to be appropriate solvents for
preparing ASDs based on … found to be appropriate solvents for ASD preparation using PVP K90…

[HTML][HTML] Pharmaceutical amorphous solid dispersion: A review of manufacturing strategies

SV Bhujbal, B Mitra, U Jain, Y Gong, A Agrawal… - … Pharmaceutica Sinica B, 2021 - Elsevier
… techniques for preparing ASDs. As physical stability is a critical quality attribute for ASD, the
Selection strategies are proposed to identify suitable manufacturing methods, which may …

Thermodynamic modeling of solvent-impact on phase separation in amorphous solid dispersions during drying

S Dohrn, P Reimer, C Luebbert… - Molecular …, 2020 - ACS Publications
… /water system showed the predicted liquid–liquid phase separation during drying and is
thus regarded as an inappropriate solvent choice for HPMCAS-based ASD preparation by …