… The clinical pharmacokinetics of allopurinol and oxypurinol have been summarised in … dose
of allopurinol. This figure has been used in the pharmacokinetic calculations of oxypurinol in …

… plasma concentration-time curve (AUC) values for oxypurinol and allopurinol after 300mg
compared with 100mg. The clinical relevance of this finding has not been established and it …

… The objective of this study was to investigate the pharmacokinetics and hypouricaemic
effect of oxypurinol (the active metabolite of allopurinol) and probenecid when administered …

… establish the pharmacokinetics (PK) of allopurinol and oxypurinol, and the pharmacodynamics
(… The dosage used and the effect of allopurinol in this population, either or not undergoing …

… Blood and urine samples were collected to measure oxypurinol and urate concentrations. …
allopurinol therapy upon plasma concentrations and renal clearances of urate and oxypurinol. …

… to develop a population pharmacokinetic model for allopurinol and oxypurinol and to
explore the influence of patient characteristics on allopurinol and oxypurinol pharmacokinetics. …

… allopurinol, it is thus relevant to relate the therapeutic effect of allopurinol with the plasma
concentration of oxypurinol. … of oxypurinol is found to correlate with allopurinol dosage [8] and it …

… In this analysis, F m was used to represent the fraction of the allopurinol dose systemically
available as oxypurinol and K fm denotes the formation rate constant, similar to a previous …

… target oxypurinol concentrations using suggested allopurinol … of variability in oxypurinol
pharmacokinetics and explore … target oxypurinol concentrations using suggested allopurinol …

… , allopurinol, oxypurinol and uric … allopurinol dose groups (allopurinol 600 mg once daily
vs 300 mg twice daily). In the twice daily regimen, AUC 0–24 values for allopurinol or oxypurinol …