… cognitive alterations characteristic of the disease. The present study intended to examine …
3xTgAD mice of both sexes present cognitive, emotional and other behavioral alterations at …

… known to lead to cognitive impairment and behavioral changes … that neonatal handling may
exert a potential modification of … first time this sex dimorphism in the 3xTg-AD mice. Moreover, …

… The risk of Alzheimer's disease (AD) is higher in women than … neonatal demasculinization
of male 3xTg-AD mice altered … approaches, mounting and stimulus bedding preference. First…

… as postnatal handling (PH), a tactile sensorial stimulation … -related cognitive or histological
changes However, the effects of … , rearings consistently showed sexual dimorphism while the …

… experience worse pathology and faster cognitive decline. Pre-clinical … modifications such as
methylation and acetylation [31]. These … and no analysis was performed on AβPP processing …

… handling exerted a preventive effect on some cognitive (spatial learning) and emotional
alterations appearing in 3xTg-AD mice … not sensorial stimulation by early-life postnatal handling …

… and cognitive impairment. Our findings indicate … age, young 3xTg mice (ie, 4 months) already
exhibit altered mRNA … The estrous cycle for both the experimental and stimulus mice were …

… -dependent pattern, with females showing earlier cognitive … (PrP) promoter show significant
sex dimorphism, with females … :APPsi mice coincided with any alterations in anxiety levels. …

… brain pathology and improve cognition and behavioral responses … regards the effect of the
EE on IL-2 levels in ConA-stimulated … to suffer AD-related alterations, and is congruent with the …

… -like and cognitive phenotypes (worse in 3xTg-AD females), and … , vascular alterations of
female 3xTg-AD mice were found … the HPA axis exhibited sexual dimorphism, with higher levels …