Control of autoimmune inflammation using liposomes to deliver positive allosteric modulators of metabotropic glutamate receptors

JM Gammon, AR Adapa… - Journal of Biomedical …, 2017 - Wiley Online Library
… We hypothesized liposomal delivery of PHCCC might enable safe, effective delivery of this
… Here, we report a new idea based on using liposomes as carriers for metabolic modulators

[HTML][HTML] Controlled delivery of a glutamate receptor modulator to promote regulatory T cells and restrain autoimmunity

JM Gammon - 2015 - search.proquest.com
… ), a small molecule positive allosteric modulator of mGluR4, can bias T … options for autoimmunity
or inflammatory disease. … liposomes on DC activation as well as the ability of PHCCC …

[HTML][HTML] A new platform for autoimmune diseases. Inducing tolerance with liposomes encapsulating autoantigens

L Almenara-Fuentes, S Rodriguez-Fernandez… - … , Biology and Medicine, 2023 - Elsevier
… Here, we show that PS-liposomes can be adapted to other autoimmuneliposomes without
PS are being used to deliver anti-inflammatory drugs to control autoimmune inflammation

[HTML][HTML] Nanotechnology approaches for enhanced CNS drug delivery in the management of schizophrenia

R Rajendran, KN Menon, SC Nair - Advanced Pharmaceutical …, 2022 - ncbi.nlm.nih.gov
… GABA receptor positive allosteric modulators … that facilitate drug transport using liposomes
and other carriers. … Metabotropic glutamate receptor is involved in the pathophysiology of …

Vitamin D deficiency induces the excitation/inhibition brain imbalance and the proinflammatory shift

LA Kasatkina, AS Tarasenko, OO Krupko… - … International Journal of …, 2020 - Elsevier
… of cholesterol was in the liposomal membranes, the less … , we studied the functioning of
metabotropic glutamate receptor type 7 (… We found that negative allosteric modulator of mGluR7 (…

Harnessing Biomaterials to Study and Direct Antigen-Specific Immunotherapy

C Edwards, ST Carey, CM Jewell - ACS Applied Bio Materials, 2023 - ACS Publications
… ), a small molecule glutamate receptor enhancer and DC metabolite. Both liposomes and …
We first tested this in a model of the autoimmune disease multiple sclerosis, wherein the …

[HTML][HTML] Advances in dendritic cell targeting nano-delivery systems for induction of immune tolerance

G Lin, J Wang, YG Yang, Y Zhang… - Frontiers in …, 2023 - ncbi.nlm.nih.gov
… potential in the treatment of autoimmune diseases, organ … Liposomes are another class of
nano-delivery systems … pro-inflammatory effects, which has negative effects in the treatment of …

Glutamatergic neurotransmission: A potential pharmacotherapeutic target for the treatment of cognitive disorders

P Chakraborty, A Dey, AV Gopalakrishnan… - Ageing Research …, 2023 - Elsevier
… Dysfunctional glutamate receptors and other glutamatergicNMDA receptors have a high
affinity for glutamate and are tightly … Fine-tuning of NMDA functions is controlled by post-…

Alzheimer's and Parkinson's disease therapies in the clinic

P Chopade, N Chopade, Z Zhao… - Bioengineering & …, 2023 - Wiley Online Library
… Note that liposomes-based delivery vehicles are binned … Muscarinic acetylcholine receptor
1 positive allosteric modulator 99 … such as memantine block glutamate receptors are tested for …

Therapeutic antibodies directed at G protein-coupled receptors

CJ Hutchings, M Koglin, FH Marshall - MAbs, 2010 - Taylor & Francis
… to identify small molecule allosteric modulators for this reason. … , reconstituted into liposomes
to raise mAbs using classical … management of chronic diseases, particularly autoimmune