Controlled phage therapy by photothermal ablation of specific bacterial species using gold nanorods targeted by chimeric phages

H Peng, RE Borg, LP Dow… - Proceedings of the …, 2020 - National Acad Sciences
… the phage immediately upon use. We accomplish this by conjugating phages to gold nanorods,
… -infrared light causes localized heating that essentially cooks nearby bacteria. Thus, the …

Treatment of Wound Infections in a Mouse Model Using Zn2+-Releasing Phage Bound to Gold Nanorods

H Peng, D Rossetto, SS Mansy, MC Jordan, KP Roos… - ACS …, 2022 - ACS Publications
… Our results demonstrate that phage therapy controlled by … a photothermal agent, AuNRs,
to the chimeric phage. Since the … , we further loaded the chimeric phages with a zinc-binding …

Plasmonically modulated gold nanostructures for photothermal ablation of bacteria

G Guan, KY Win, X Yao, W Yang… - Advanced Healthcare …, 2021 - Wiley Online Library
… well-localized heating in bacteria for controlling a great … a small amount of platinum in
gold nanoparticles results in a … , AuNRs were conjugated with chimeric phages that attached …

Gold-decorated M13 I-forms and S-forms for targeted photothermal lysis of bacteria

TT Ngo-Duc, Z Alibay, JM Plank… - … applied materials & …, 2019 - ACS Publications
… are of specific interest as photothermal bactericidal agents. … to estimate the number of gold
nanoparticles per template. OD … the target, such as the gold colloid used in the control sample, …

Bacteriophages and phage-inspired nanocarriers for targeted delivery of therapeutic cargos

M Karimi, H Mirshekari, SMM Basri, S Bahrami… - Advanced drug delivery …, 2016 - Elsevier
… and controlled manner, and the major limitation of phages for … with plasmon-resonant
gold nanoparticles could generate a … Production of MS2-coat-retrovirus chimeras is a recent …

Phages and nanotechnology: new insights against multidrug-resistant bacteria

M Pardo-Freire, P Domingo-Calap - BioDesign Research, 2023 - spj.science.org
phage therapy, consists in the use of phages as therapeutic … (B) Use of phages conjugated
with gold nanorods (AuNRs) … A chimeric M13 phage recognizing P. aeruginosa was …

Chimeric phage nanoparticles for rapid characterization of bacterial pathogens: detection in complex biological samples and determination of antibiotic sensitivity

H Peng, RE Borg, ABN Nguyen, IA Chen - ACS sensors, 2020 - ACS Publications
… of the phages induced aggregation of gold nanoparticles (AuNPs)… are AuNPs with no bacteria
or phages, control (10 6 CFU … of specific bacterial strains by chimeric, thiolated phages and …

Preparation of Bioconjugates of Chimeric M13 Phage and Gold Nanorods

H Peng, IA Chen - Phage Engineering and Analysis: Methods and …, 2024 - Springer
… weakening the binding affinity to the bacterial host cells. Herein, … We previously reported the
rational design of chimeric phages … For photothermal therapy, we developed a technique to …

Engineering M13 Bacteriophage Nanoplatforms for Diagnostic and Therapeutic Applications

U Tsedev - 2021 - dspace.mit.edu
… within targeted, cationically modified, ‘inho’ phages are able to … While phage therapy and
clinical use was never abandoned … A) Size control of phages length and cssDNA: inho phage

Delivery of Therapeutics Using Bacteriophage Vectors

S Venkataraman, M Shahgolzari, A Yavari, K Hefferon - 2024 - preprints.org
chimeric vector to deliver targeted suicide gene therapy to … breast tumor-targeting peptide
and conjugated it to gold nanorods, … of phage therapy, such that bacteriophages loaded with a …