… In summary, the two-centre study demonstrated that the neuropathological stages can be
mapped in vivo in PLS with high reproducibility and that PLS-associated cerebral propagation, …

… imaging (DTI) data from PLS patients by a hypothesis-guided tract-of-interest-based approach
… Accordingly, maps of the other DTI metrics were used to perform the equivalent analysis, …

… In summary, the tract-specific DTI analysis demonstrated the same alterations of ALS-… on
the other hand, like also in primary lateral sclerosis or in the lower motor neuron disease variant…

… differ from the ‘classical’ involvement of the upper and the lower … hand, the diagnostic criteria
for primary lateral sclerosis as a slowly … In summary, the tract-of-interest-based DTI analysis …

… and all patients had negative results at genetic analysis for the Cu/Zn SOD-1 … involved the
lower limbs, and in 10 patients it had involved the upper limbs. No bulbar onset or involvement …

… Neuroimaging has the potential to play an important role in the evaluation of novel … and
diffusion tensor imaging analyses. Morphometric structural analyses of PLS brain invariably …

… DTI … analyses where out of the entire cerebral white matter skeleton strikingly focal and
anatomically meaningful correlations were observed in the fibres of the corticospinal tracts …

… Thalamic white matter involvement was also detected across all diffusivity measures. While
no … matter analyses not only confirm the pathognomonic degeneration of the pyramidal tracts, …

… level by fiber-tract of interest (TOI)-based DTI mapping, ie, a … of DTI-based cross-sectional
and longitudinal analyses in ALS … neuron disease (LMND) and primary lateral sclerosis (PLS). …

… Diffusion tensor imaging (DTI) can identify amyotrophic lateral sclerosis (ALS… DTI study
including the tract-of-interest-based analysis showed a microstructural corticoefferent involvement …