… virus (BIV) integrase has the same function as HIV-1 integrase. We have determined crystal
structures of the BIV integrase catalytic core domain (CCD) in two different crystal forms at a …

… of X-ray crystal structures of active integrase-DNA complexes … bonds on opposing strands
of target DNA (tDNA) across the … Two-domain X-ray crystal structures revealed variable CCD-…

… domains (NTD and CCD) of HIV-2 IN in complex with the IN … of HIV inhibitors that target the
integrase–LEDGF interaction. … interface bears a special significance for concerted lentiviral …

… Integrase (IN) is an important therapeutic target in the search … with potential biological
implications. Our experimental data … The DNA sequence encoding the IN catalytic core domain of …

… its significance as a model for detailed structural studies. … , target their integration via direct
interaction between their INs and … Our crystal structure also explains the phenotype of a more …

… integrates one viral DNA end into target DNA. We also show … The crystal structures, combined
with earlier structural … , as opposed to the detrimental effect of W259A itself, may reflect the …

… of homology between two recombining overlap regions has little effect on target site selection
or … of informative crystal structures: the isolated catalytic domain of Int (112), the dimerized …

… In the crystal structure of core domain IN in complex with 5-… We also examined the effect of
inhibitor binding on the … to the catalytic core domain, thus preventing the target DNA substrate …

… and EIAV integration resulted in 5 bp duplications of the target DNA sequences. … structure
of the isolated IBD and a crystal structure of the IBD in complex with the catalytic core domain (…

… with the catalytic domains of the lambda-type integrases and … of developmental stage specific
target genes and maintain the … Crystal structure of the intein homing endonuclease PI-SceI …