Cytochrome P450-mediated changes in oxycodone pharmacokinetics/pharmacodynamics and their clinical implications
KC Söderberg Löfdal, ML Andersson, LL Gustafsson - Drugs, 2013 - Springer
… do not seem to have any significant clinical impact. … the clinical effect of oxycodone. This
is in contrast to CYP3A4, but not surprising as it is the major metabolic pathway for oxycodone. …
is in contrast to CYP3A4, but not surprising as it is the major metabolic pathway for oxycodone. …
Updated clinical pharmacokinetics and pharmacodynamics of oxycodone
M Kinnunen, P Piirainen, H Kokki, P Lammi… - Clinical …, 2019 - Springer
… and adverse effects of oxycodone are inconsistent. … changes in a female body that affect
body composition and gastrointestinal, circulatory, renal and hepatic functions. These changes …
body composition and gastrointestinal, circulatory, renal and hepatic functions. These changes …
[PDF][PDF] The Role of Cytochrome P450 3A Inducers and Inhibitors in the Metabolism and the Effects of Oxycodone
T Nieminen - 2010 - utupub.fi
… Pain is a common reason for medical interventions. Pain patients are often treated with a …
, no significant changes in the AUC of oxycodone was observed, suggesting the negligible …
, no significant changes in the AUC of oxycodone was observed, suggesting the negligible …
Individual variability in clinical effect and tolerability of opioid analgesics–importance of drug interactions and pharmacogenetics
V Solhaug, E Molden - Scandinavian journal of pain, 2017 - degruyter.com
… in PubMed to identify literature highlighting the clinical impact of drug interactions and …
substantially reduce exposure and clinical effect of fentanyl and oxycodone, which are inactivated …
substantially reduce exposure and clinical effect of fentanyl and oxycodone, which are inactivated …
Pharmacogenomics of oxycodone: a narrative literature review
NN Umukoro, BW Aruldhas, R Rossos… - …, 2021 - Future Medicine
… Though there were no changes in pharmacokinetic outcomes of … of oxycodone’s metabolites
to the overall clinical effects and impact on inter-individual variations in clinical effects. …
to the overall clinical effects and impact on inter-individual variations in clinical effects. …
The effects of CKD on cytochrome P450–mediated drug metabolism
MA Ladda, KB Goralski - Advances in chronic kidney disease, 2016 - Elsevier
… now exists an abundance of evidence demonstrating that CKD can impact the activity of many
… of the effects that CKD can have on CYP metabolism and also discusses the impact that …
… of the effects that CKD can have on CYP metabolism and also discusses the impact that …
The effect of anlotinib on the pharmacokinetic profile of oxycodone and the underlying mechanism
G Lin, Z Ye, N Gao, X Hu, Q Kong, X Zhang… - Chemico-Biological …, 2022 - Elsevier
… of great significance to study whether there is an interaction between anlotinib and oxycodone.
… a single administration of anlotinib, there was no significant change in the metabolism of …
… a single administration of anlotinib, there was no significant change in the metabolism of …
A systematic in vitro metabolism study of opioids using rat liver S9 fractions and mass spectrometry revealed CYP2D metabolism is impaired with age
SF Salmin - 2017 - papyrus.bib.umontreal.ca
… The outcome of the treatment is ultimately related to their … lead to severe consequences
including alterations in their efficacy, … oxycodone were used to characterize functional changes …
including alterations in their efficacy, … oxycodone were used to characterize functional changes …
Pharmacokinetic and pharmacodynamic considerations in developing a response to the opioid epidemic
R Balyan, D Hahn, H Huang… - Expert opinion on drug …, 2020 - Taylor & Francis
… effects associated with the administration of oxycodone in … This relatively small structural
change appears to impact the … to participate in Cytochrome P450-mediated metabolism in the …
change appears to impact the … to participate in Cytochrome P450-mediated metabolism in the …
[图书][B] Pharmacokinetics II: cytochrome P450-mediated drug interactions
JR Oesterheld, DA Flockhart, A Martin, L Scahill… - 2003 - books.google.com
… Another vignette illustrates the importance of clinical effects beginning sometime after the …
of plasma concentration changes but not the pharmacodynamic consequences of them. …
of plasma concentration changes but not the pharmacodynamic consequences of them. …