Cytotoxic interaction between amiodarone and desethylamiodarone in human peripheral lung epithelial cells
FC Roth, JE Mulder, JF Brien, T Takahashi… - … -biological interactions, 2013 - Elsevier
… with AM to cause lung toxicity. The objective of this study was to determine the type …
cytotoxic interaction between AM and DEA in HPL1A human peripheral lung epithelial cells. …
cytotoxic interaction between AM and DEA in HPL1A human peripheral lung epithelial cells. …
Mechanisms of amiodarone and desethylamiodarone cytotoxicity in nontransformed human peripheral lung epithelial cells
JE Mulder, JF Brien, WJ Racz, T Takahashi… - Journal of …, 2011 - ASPET
… Therefore, a RAS-independent mechanism seems to be responsible for AM and DEA
cytotoxicity in nontransformed human lung epithelial cells; however, our findings do not preclude …
cytotoxicity in nontransformed human lung epithelial cells; however, our findings do not preclude …
[PDF][PDF] Mechanisms of Amiodarone and Desethylamiodarone Cytotoxicity in Human Lung Cells
JE Black - Master of Science thesis, 2009 - qspace.library.queensu.ca
… amiodarone-induced pulmonary toxicity. In cultured HPL1A human peripheral lung epithelial
cells, … h of incubation, indicating that the HPL1A cell culture model can be used to study the …
cells, … h of incubation, indicating that the HPL1A cell culture model can be used to study the …
[HTML][HTML] Amiodarone induces apoptosis of human and rat alveolar epithelial cells in vitro
R Bargout, A Jankov, E Dincer… - … -Lung Cellular and …, 2000 - journals.physiology.org
… antiarrhythmic amiodarone (AM) and its metabolite desethylamiodarone (… cytotoxic for other
pulmonary cell types. Furthermore, we show that a significant component of the cytotoxicity is …
pulmonary cell types. Furthermore, we show that a significant component of the cytotoxicity is …
[图书][B] Mechanisms of Amiodarone and N-desethylamiodarone Toxicity in Lung Cells
MW Bolt - 2002 - library-archives.canada.ca
… pulmonary fibrosis. Susceptibilities of different hamster lung cell types to AM-induced cytotoxicity
… AM (1 00 and 200 bM)induced cytotoxicity was significantly greater in hamster alveolar …
… AM (1 00 and 200 bM)induced cytotoxicity was significantly greater in hamster alveolar …
Activation of autophagy rescues amiodarone-induced apoptosis of lung epithelial cells and pulmonary toxicity in rats
KY Lee, S Oh, YJ Choi, SH Oh, YS Yang… - toxicological …, 2013 - academic.oup.com
… Both amiodarone and desethylamiodarone tend to … mTOR inhibition in H460 human lung
epithelial cells. This study is … aggravated the cytotoxicity of amiodarone in H460 cells, whereas …
epithelial cells. This study is … aggravated the cytotoxicity of amiodarone in H460 cells, whereas …
Direct mitochondrial dysfunction precedes reactive oxygen species production in amiodarone-induced toxicity in human peripheral lung epithelial HPL1A cells
AC Nicolescu, Y Ji, JL Comeau, BC Hill… - Toxicology and applied …, 2008 - Elsevier
… in AIPT, were susceptible to the toxicity of AM and N-desethylamiodarone (DEA), a major …
event in AM-induced cytotoxicity in pulmonary epithelial cells. Cytoplasmic translocation of …
event in AM-induced cytotoxicity in pulmonary epithelial cells. Cytoplasmic translocation of …
Effects of metabolites and analogs of amiodarone on alveolar macrophages: structure-activity relationship
D Quaglino, HR Ha, E Duner… - … -Lung Cellular and …, 2004 - journals.physiology.org
… Amiodarone, an antiarrhythmic drug toxic toward the lung, is … mono-N-desethylamiodarone
(MDEA), di-N-desethylamiodarone (DDEA), and … and rat alveolar epithelial cells. Am J Physiol …
(MDEA), di-N-desethylamiodarone (DDEA), and … and rat alveolar epithelial cells. Am J Physiol …
Amiodarone: review of pulmonary effects and toxicity
SA Papiris, C Triantafillidou, L Kolilekas, D Markoulaki… - Drug safety, 2010 - Springer
… , amiodarone is metabolized to N-desethylamiodarone, an … ‘cytotoxic’ effect to type II
pneumocytes, as well as other cells … shown that amiodarone induces alveolar epithelial cell (AEC…
pneumocytes, as well as other cells … shown that amiodarone induces alveolar epithelial cell (AEC…
Mechanisms of amiodarone pulmonary toxicity
WJ Martin II - Clinics in chest medicine, 1990 - Elsevier
… 1), it is possible that both amiodarone and desethylamiodarone ex… cytotoxic and suppressor
function;" In the microenvironment of the alveolar capillary structure, lung parenchymal cells …
function;" In the microenvironment of the alveolar capillary structure, lung parenchymal cells …