… (1) and the 7-azaindenoisoquinolines produce significantly more DNA damage in an acute
… provides new halogenated 7-azaindenoisoquinolines that are selectively cytotoxic to cancer …

… that some of the 7-azaindenoisoquinolines had the ability to … research led to very potent
cytotoxic anticancer agents, it also … rewarded with the extremely cytotoxic 3-fluoro derivative 62 (…

… chance to develop more effective anticancer drugs in addition to those … Design and Synthesis
of Chlorinated and Fluorinated 7-Azaindenoisoquinolines as Potent Cytotoxic Anticancer …

… potential anticancer agents targeting Topoisomerase I (TOP1), … synthesis of compounds with
different scaffolds can inhibit … TOP1 poisoning activity of the most potent cytotoxic 4-alkoxy-2-…

… topoisomerase inhibition as antitumor agent in clinical usage. … 2) exhibited the most potent
cytotoxicity against several cell … more potent than camptothecin, and about 6–fold more potent …

… anticancer drugs, dual-downregulation of MYC and … in Raji vs CA-46 cells and cytotoxicity
in MYC-dependent cell lines. … the design and synthesis of new 7-azaindenoisoquinolines and …

… Recently, we have developed a new series of 6,7-dimethoxy-4-alkoxy-2-arylquinolines as
Topoisomerase I (TOP1) inhibitors with potent anticancer activity. Utilising the SAR outputs …

… in 7-azaindenoisoquinolines was also replaced by a chlorine … -chloro and 3-fluoro 7-azaindenoisoquinolines
were less toxic … develop anticancer drugs as both Tdp1 and Tdp2 inhibition …

… to inhibition of one class of topoisomerase enzymes is … in the development of potent, efficient
and safe anticancer agents. … only few differences in their cytotoxicity activity, which could …

… may hinder intercalation in dsDNA due to possible steric collision with the DNA backbone.
Interestingly, the 3-fluoro-substituted 7-azaindenoisoquinolines 5 … useful anticancer drugs and …