… 1-Methyl-3-phenyl-5-(p-tolyl)-4,5-dihydro-1H-pyrazole 3g was the most potent hMAO-B
inhibitor … In comparison with the reference inhibitors, 3g was at least 2-fold more active. The …

… Design, synthesis, and in vitro hMAO-B inhibitory evaluation of some 1-methyl-3, 5-diphenyl-4,
5-dihydro-1H-pyrazoles. Bioorg Med Chem Lett 2013; 23 (18): 5128-30. …

… These chalcone analogues were moderate hMAO-B inhibitors; some derivatives
inhibited hMAO-B with IC 50 values in the submicromolar range. However, Br- and Cl-substituted …

… designed a series of 1-methyl-3, 5diphenyl-4, 5-dihydro-1H-pyrazoles (47) and these were
synthesized … Most of the derivatives were found to be potent and selective hMAO-B inhibitors. …

… were designed and synthesized to be evaluated as selective human MAO-B inhibitors. A …
The compounds were tested for their inhibitory activities on both human MAO-A and B. All …

… This inhibitory versatility is related to the plasticity of the hMAO-B active site cavity. As
described above, the cavity can hold small inhibitors such as isatin and tranylcypromine, or cavity-…

… al designed and synthesized a series of 1-methyl-3,5-diphenyl4,5-dihydro-1H-pyrazoles, and
evaluated for their inhibitory … hMAO-B inhibitors. In particular, derivative 51 showed greater …

… and design of reversible and selective inhibitors for MAO-A or MAO-B isoforms has been
emphasized in ongoing research. This review … ve izatin-hMAO-B enzim kompleksinde izatindeki …

… the inhibiting ability of 1-acetyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazole derivatives to amine
oxidases activity; Ozdemir [8] have synthesized some 1-… a simple procedure to synthesize bis-…

… -pyrazoles was synthesized and studied as inhibitors of furin. … the activity of furin by mixed-type
inhibition with K = 288 microM. … design more potent furin inhibitors of non-peptide nature. …