… identify the role of poly(ADP-ribose) polymerase (PARP) in cerebrovascular dysfunction in
… rats, PJ-34 alleviated T1D-induced impairment of NOS-dependent vasodilation. We also …

… Reversal of diabetes-induced cardiac dysfunction by pharmacological inhibition of PARP
in an autoimmune mouse model of diabetes. Effect of diabetes and PJ34 on left ventricular …

… stress–PARP pathway leads to diabetes-induced endothelial dysfunction, which may be an
… Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia. …

… conditions of the development of cerebral dysfunctions induced by experimental type-1
DM. … Kuchmerovska, “Diabetes-induced impairments of the exocytosis process and effect of …

… affecting the cardiac and cerebrovascular circulation, which … the possibility that
diabetes-induced endothelial dysfunction is … The coincident activities of PARP and poly …

… Recently we proposed the importance of oxidant-induced DNA strand breakage and …
poly(ADP-ribose) polymerase (PARP) in the pathogenesis of diabetic endothelial dysfunction. In …

… (Figure) is not limited to the diabetes-induced vascular dysfunction but is also relevant for
the … gene dis-ruption renders mice resistant to cerebral ischemia. Nat Med 3: 1089-1095. …

… of poly(ADP-ribose) polymerase (PARP) is an important factor in the pathogenesis of
endothelial dysfunction in … Figure 1: Reversal of diabetes-induced endothelial dysfunction by …

… and diabetes-induced retardation of normal nerve growth and maturation; and 2) PARP
inhibitor treatment acts on both components with predominant effect on diabetes-induced …

… inhibition on diabetes-induced oxidative-nitrosative stress and poly(ADP-ribose) polymerase
(PARP) … Fidarestat prevented the diabetes-induced increase in nitrotyrosine (a marker of …