Differential involvement of glutamatergic mechanisms in the cognitive and subjective effects of smoking

A Jackson, J Nesic, C Groombridge, O Clowry… - …, 2009 - nature.com
… , but neither drug altered this effect. Our results suggest that glutamatergic mechanisms
may have differential involvement in the subjective and cognitive actions of …

A role for glutamate in subjective response to smoking and its action on inhibitory control

J Nesic, T Duka, JM Rusted, A Jackson - Psychopharmacology, 2011 - Springer
… a study to investigate the effects of DCS on the cognitive and subjective effects of … smoked
a whole cigarette, thus differential self-dosing produced a different profile of subjective effects. …

[HTML][HTML] Mechanistic insights into the efficacy of memantine in treating certain drug addictions

C Montemitro, A Angebrandt, TY Wang… - Progress in Neuro …, 2021 - Elsevier
… was associated with increased subjective effects of alcohol, … Thus, this mechanism can
account for the differential efficacy of … high glutamate in alcohol withdrawal, and moderately high …

Cue reactivity in nicotine and tobacco dependence: a “multiple-action” model of nicotine as a primary reinforcement and as an enhancer of the effects of smoking …

C Chiamulera - Brain Research Reviews, 2005 - Elsevier
… brain processes and mechanisms underlying smokers' cue reactivity. Smoking behaviour is
… of smoking and nicotine-associated stimuli. In fact, it is widely reported that the exposure of …

Cognitive enhancers in the treatment of substance use disorders: clinical evidence

KT Brady, KM Gray, BK Tolliver - Pharmacology Biochemistry and Behavior, 2011 - Elsevier
glutamatergic systems have shown potential for improving … The high rate of cigarette
smoking in schizophrenia has led … reduced positive subjective effects of methamphetamine …

Glutamatergic medications for the treatment of drug and behavioral addictions

MF Olive, RM Cleva, PW Kalivas, RJ Malcolm - … Biochemistry and Behavior, 2012 - Elsevier
… pharmacological mechanisms of action and general clinical efficacy of glutamatergic medications
… increased the subjective effects of withdrawal from smoking as well as the rewarding …

Effect of varenicline on aspects of inhibitory control in smokers

AJ Austin, T Duka, J Rusted, A Jackson - Psychopharmacology, 2014 - Springer
… studies investigating the effects of the … glutamate on the cognitive and subjective effects of
smoking, we found evidence for the involvement of glutamate in some of the subjective effects

Cognitive effects of Group I metabotropic glutamate receptor ligands in the context of drug addiction

MF Olive - European journal of pharmacology, 2010 - Elsevier
… the psychoactive ingredients of cigarette smoke (ie, nicotine) … possible explanation is a
differential involvement of mGlu 5 … to drug craving and subjective drug effects? Several mGlu 5 (…

Glutamate and the neural basis of the subjective effects of ketamine: a pharmaco–magnetic resonance imaging study

JFW Deakin, J Lees, S McKie, JEC Hallak… - Archives of general …, 2008 - jamanetwork.com
effects of ketamine are mediated by increased glutamate release. … results are compatible
with the theory that the neural and subjective effects of ketamine involve increased glutamate

Optimizing treatments for nicotine dependence by increasing cognitive performance during withdrawal

RL Ashare, HD Schmidt - Expert opinion on drug discovery, 2014 - Taylor & Francis
… the release and function of glutamate, particularly in brain regions important for … cognitive
flexibility Citation[71]. DCS also had differential effects on the subjective symptoms of smoking