… -3H-imidazol-4-yl]-pyridin-2-yl}-acetamide (CBS-3595), a Dual p38α … , 1, a dual p38α
MAPK/PDE4 inhibitor, was discovered by coincidence in quest of a dual p38α MAPK/JNK3 inhibitor. …

… characteristics of p38α, its relationship to the fore-mentioned disease states, … An additional
evidence supporting this finding is that p38α can negatively … Compound 6 (CBS-3595, Fig. …

… , a dual inhibitor of p38α MAPK and PDE4 was discovered … Subsequently, the metabolically
stable compound CBS-3595 (… bipolar disorder, such as its antioxidant activity and inhibition …

… Here, two series of novel ursolic acid-based 1,2,4-triazolo[1,5… anti-inflammatory activity by
evaluating their inhibition effect of … agents for the treatment of inflammatory diseases [22]. In …

… Nevertheless, the function of rottlerin on Crohn disease (CD) … Among PDEs, PDE-4 is thought
to inhibit a variety of … our research, and we discovered that rottlerin treatment reduced the …

… One gram of solid NaCl was added to the samples (to inhibit … The following conditions were
used for analyses: initial … , we were largely unsuccessful in finding any fruit bodies of desert …

… The scan rate dependence of the thermal evolution of the spatially averaged HS fraction is
displayed in Figure 4a, where we observe that the hysteresis is becoming increasingly broad …

… have wide applications ranging from discovery of new bioactive … is very sensitive to the
reaction conditions and, also, on the … knowledge, there are no reported conditions in the literature …

… 4 inhibitors in inflammatory lung diseases: dual-selective phosphodiesterase … Discovery
of a novel class of phosphodiesterase 10A inhibitors and identification of clinical candidate 2-[4…

… 4 inhibitors in inflammatory lung diseases: dual-selective phosphodiesterase … Discovery
of a novel class of phosphodiesterase 10A inhibitors and identification of clinical candidate 2-[4…