Discrepancies between different rat models for the assessment of percutaneous penetration of hazardous substances
G Korinth, T Göen, KH Schaller, H Drexler - Archives of toxicology, 2007 - Springer
… percutaneous absorption of hazardous substances in humans. In our study, the percutaneous
penetration of 2-butoxyethanol (BE) and toluene was compared in different rat models. …
penetration of 2-butoxyethanol (BE) and toluene was compared in different rat models. …
Percutaneous penetration studies for risk assessment
P Sartorelli, HR Andersen, J Angerer, J Corish… - Environmental …, 2000 - Elsevier
… Toxic substances are present in workplaces and the … In vitro/in vivo comparison using animal
models can also be … There are considerable differences between the two standards with …
models can also be … There are considerable differences between the two standards with …
Percutaneous Penetration‐Methodological Considerations
R Holmgaard, E Benfeldt… - Basic & clinical …, 2014 - Wiley Online Library
… skin penetration research is to assess the risk to human beings after dermal exposure to
hazardous chemicals… both physiological and structural differences between species, which may …
hazardous chemicals… both physiological and structural differences between species, which may …
Evaluation of in-vivo animal and in-vitro models for prediction of dermal absorption in man
I Jakasa, S Kezic - Human & experimental toxicology, 2008 - journals.sagepub.com
… animal models are still valuable for dermal risk assessment. … predictions of dermal absorption
of toxic chemicals’’ (EDETOX)… The pig as an experimental animal model of percutaneous …
of toxic chemicals’’ (EDETOX)… The pig as an experimental animal model of percutaneous …
Comparison of the human skin grafted onto nude mouse model with in vivo and in vitro models in the prediction of percutaneous penetration of three lipophilic …
A Capt, AP Luzy, D Esdaile, O Blanck - Regulatory Toxicology and …, 2007 - Elsevier
… at 24 h, while rat models overestimated the human skin … indicated that evaluation of %
percutaneous absorption over … This in vivo/in vitro difference was not observed in the rat models, …
percutaneous absorption over … This in vivo/in vitro difference was not observed in the rat models, …
Evaluation of animal models for predicting skin penetration in man
WG Reifenrath, EM Chellquist… - Toxicological …, 1984 - academic.oup.com
… was fairly close agreement among the percutaneous penetration values determined for DEM
… Hg at 20Q may limit skin penetration to the extent that differences between the models fade. …
… Hg at 20Q may limit skin penetration to the extent that differences between the models fade. …
Percutaneous penetration and absorption of parathion using human and pig skin models in vitro and human skin grafted onto nude mouse skin model in vivo
I Boudry, O Blanck, C Cruz, M Blanck… - Journal of Applied …, 2008 - Wiley Online Library
… skin to PA in vivo was assessed by comparing our results with … in vivo and in vitro human
and animal skin penetration data and (b) … difference, the absorption of PA in the pig skin model …
and animal skin penetration data and (b) … difference, the absorption of PA in the pig skin model …
Significance of the dermal route of exposure to risk assessment
DR Mattie, JH Grabau, JN McDougal - Risk Analysis, 1994 - Wiley Online Library
… differences in penetration rates is necessary in order to extrapolate animal data from PBPK
models … The PCs were considered as predictors of percutaneous penetration for the purpose …
models … The PCs were considered as predictors of percutaneous penetration for the purpose …
The significance of in vitro rat skin absorption studies to human risk assessment
B Van Ravenzwaay, E Leibold - Toxicology in vitro, 2004 - Elsevier
… penetration between rat and man for a total of 14 chemicals in … demonstrating large differences
in the rate of skin penetration. … Rat skin is the membrane type of choice in percutaneous in …
in the rate of skin penetration. … Rat skin is the membrane type of choice in percutaneous in …
Evaluation of in vitro vs. in vivo methods for assessment of dermal absorption of organic flame retardants: a review
… assumed values for percutaneous penetration of various flame … The difference between the
calculated PA values for soil … when extrapolating results from animal models to humans. This …
calculated PA values for soil … when extrapolating results from animal models to humans. This …