Disruption of the Notch pathway aggravates airway inflammation by inhibiting regulatory T cell differentiation via regulation of plasmacytoid dendritic cells
SY Qu, XY Ti, J Zhang, C Wu - Scandinavian Journal of …, 2020 - Wiley Online Library
… in pDC-mediated asthmatic airway inflammation is unclear. This study clarified the effects
of Notch signalling on pDC-mediated airway inflammation using murine models of ovalbumin-…
of Notch signalling on pDC-mediated airway inflammation using murine models of ovalbumin-…
Particulate matter of 2.5 μm or less in diameter disturbs the balance of TH17/regulatory T cells by targeting glutamate oxaloacetate transaminase 1 and hypoxia …
L Sun, J Fu, SH Lin, JL Sun, L Xia, CH Lin, L Liu… - Journal of Allergy and …, 2020 - Elsevier
… an asthma model with CD4 + T cell–specific aryl hydrocarbon … cell types: mast cells,
macrophages, dendritic cells, T cells, … and, in part, through metabolic disturbance in vitro and in …
macrophages, dendritic cells, T cells, … and, in part, through metabolic disturbance in vitro and in …
Regulatory T cells and T helper 17 cells in viral infection
Z Wan, Z Zhou, Y Liu, Y Lai, Y Luo… - Scandinavian Journal …, 2020 - Wiley Online Library
… NS1 inhibited T cell differentiation via mono-ubiquitination of … In addition, plasmacytoid
dendritic cells (pDCs) may play a … Thus, balance between these two cell subsets was disrupted. …
dendritic cells (pDCs) may play a … Thus, balance between these two cell subsets was disrupted. …
Blocking the NOTCH pathway inhibits vascular inflammation in large-vessel vasculitis
K Piggott, J Deng, K Warrington, B Younge, JT Kubo… - Circulation, 2011 - Am Heart Assoc
… wall dendritic cells to differentiate into vasculitic T cells. The … To confirm that DAPT was efficient
in disrupting NOTCH signaling, … T-cell subsets is supported by the finding that regulatory T …
in disrupting NOTCH signaling, … T-cell subsets is supported by the finding that regulatory T …
Zinc induces dendritic cell tolerogenic phenotype and skews regulatory T cell–Th17 balance
MM George, K Subramanian Vignesh… - The Journal of …, 2016 - journals.aai.org
… of dendritic cells (DCs) that are important in shaping T cell … DCs inhibit effector T cell
responses through mechanisms … or Th2 cells through the Notch signaling pathway under specific …
responses through mechanisms … or Th2 cells through the Notch signaling pathway under specific …
Thymic stromal lymphopoietin interferes with airway tolerance by suppressing the generation of antigen-specific regulatory T cells
L Lei, Y Zhang, W Yao, MH Kaplan… - The Journal of …, 2011 - journals.aai.org
… breakdown of immune tolerance and generation of inducible … -derived dendritic cells (DCs)
in vitro to up-regulate MHC II … of T cell activation was sufficient to inhibit Treg development …
in vitro to up-regulate MHC II … of T cell activation was sufficient to inhibit Treg development …
Regulatory T-cells in asthma
H Harb, TA Chatila - Current Opinion in Allergy and Clinical …, 2023 - journals.lww.com
… ) and plasmacytoid dendritic cells (pDCs) are the main cells … breakdown and the upregulation
of proinflammatory cell … The transcription factor Foxp3 shapes regulatory T cell identity by …
of proinflammatory cell … The transcription factor Foxp3 shapes regulatory T cell identity by …
Regulatory T Cells in Dominant Immunological Tolerance
… cell populations in the lung, including plasmacytoid dendritic … specific disruption of Notch
signaling enhances Treg cell … Control of regulatory T cell development by the transcription …
signaling enhances Treg cell … Control of regulatory T cell development by the transcription …
Dendritic cell-mediated T cell polarization
EC de Jong, HH Smits, ML Kapsenberg - Springer seminars in …, 2005 - Springer
… influence the T cell polarizing capacity of dendritic cells and … for the induction of regulatory
T cell development. However, … , 113], members of the Notch signaling pathway (Serrate1) [47, …
T cell development. However, … , 113], members of the Notch signaling pathway (Serrate1) [47, …
[HTML][HTML] Dendritic cells and their immunotherapeutic potential for treating type 1 diabetes
FU Khan, P Khongorzul, AA Raki… - International journal of …, 2022 - mdpi.com
… results from the destruction of pancreatic beta cells through a … and expansion of regulatory
T cell populations. Therapies that … IFN-γ producing plasmacytoid dendritic cells are recruited to …
T cell populations. Therapies that … IFN-γ producing plasmacytoid dendritic cells are recruited to …