Diurnal variation in the biliary excretion of flomoxef in patients with percutaneous transhepatic biliary drainage

S Hishikawa, E Kobayashi, K Sugimoto… - British journal of …, 2001 - Wiley Online Library
… The period that biliary flomoxef remained above the minimal inhibitory … that biliary excretion
of flomoxef shows diurnal variation. However, as the difference was relatively small, flomoxef

Dosing-time-dependent variation in biliary excretion of flomoxef in rats

S Hishikawa, K Sugimoto, E Kobayashi… - Chronobiology …, 2003 - Taylor & Francis
… of the anionic oxacephem antibiotic flomoxef (FMOX), … to patients with percutaneous
transhepatic biliary drainage (… -over design, and drained biliary fluid was collected thereafter …

The role of circadian timing system on drug metabolism and detoxification

F Gachon, D Firsov - Expert opinion on drug metabolism & …, 2011 - Taylor & Francis
biliary excretion of drugs (eg, flomoxef) presents a diurnal pattern in patients with percutaneous
transhepatic biliary drainagediurnal variations, resulting probably from diurnal changes

Understanding the role of chronopharmacology for drug optimization: what do we know?

A Fujimura, K Ushijima - Expert Review of Clinical Pharmacology, 2023 - Taylor & Francis
… of drugs in bile also shows circadian variation. However, … 09:00 in patients with cancer who
had undergone percutaneous … as it reports that the biliary excretion of flomoxef is greater after …

Chronopharmacology and antimicrobial therapeutics

M Rebuelto - Current clinical pharmacology, 2006 - ingentaconnect.com
… However, plasma concentrations of flomoxef, bile flow, and acid bile excretion did … Diurnal
variation in the biliary excretion of flomoxef in patients with percutaneous transhepatic biliary

Pharmacokinetics-based chronotherapy

D Lu, Z Wang, B Wu - Current Drug Metabolism, 2022 - ingentaconnect.com
… to a daily variation in drug exposure caused by circadian … , probably resulting from circadian
variations in OCT2mediated … Biliary excretion of flomoxef is greater in the early rest phase …

Chronopharmacology: new insights and therapeutic implications

R Dallmann, SA Brown, F Gachon - Annual review of …, 2014 - annualreviews.org
… Finally, circadian immune regulation results in diurnal variationsbiliary excretion of drugs,
for example ampicillin (100) and flomoxef, exhibits a diurnal pattern in rats (101) and patients

Role of pharmacokinetics in chronotherapeutics

D Lu, Y Wang, M Chen, H Zhao, D Dong - Circadian Pharmacokinetics, 2020 - Springer
circadian variations when drugs are administered via oral route, but no … patients receiving
percutaneous biliary drainage, biliary excretion of drugs such as ampicillin and flomoxef

Circadian rhythmic hepatic biliary flow, constituents, concentrations and excretory rates in patients after cholecystectomy.

KJ Ho - Chronobiologia, 1994 - europepmc.org
patients with indwelling common bile duct T-tube were selected for the study of circadian
fluctuation of biliary excretion. … was well reestablished a 5 ml bile sample was collected at the …

Obstetric and gynaecological anaesthesia

MJ Bohan, KJ Henderson - labour, 2001 - journals.lww.com
Ai M, Tanaka A, Ogita K, Sekinc M, Numano F, Reaven GM. Relationship between plasma
insulin concentration and plasma remnant lipoprotein response to an oral fat load in patients