… in determining the pharmacokinetic characteristics of amlodipine. In conclusion, amlodipine
pharmacokinetics was affected by the polymorphic ABCB1 gene in humans. These findings …

… 8) Kim, KA, Park, PW and Park, JY: Effect of ABCB1 (MDR1) haplotypes derived from
G2677T/C3435T on the pharmacokinetics of amlodipine in healthy subjects. Br. J. …

… Multidrug resistance 1 (MDR1), which is also known as ABCB1 or P… Twenty healthy volunteers
whose genotypes had been … of cyclosporine, tacrolimus and amlodipine [13–16] , but their …

… The aim of this study was to determine the impact of ABCB1 (MDR1… we can infer that
amlodipine pharmacokinetics is affected by … Kim et al suggested that haplotype analysis rather …

… to ABCB1, CYP3A5. Materials and methods. Antihypertensive efficacy and tolerability of
amlodipine was evaluated in 100 patients … on the genotypes of the ABCB1 and CYP3A5 genes. …

… , only the pharmacokinetic data of Nimotop were used. … can influence the disposition of
amlodipine, a dihydropyridine … in a limited number of healthy subjects. Further large sample …

… aspects: 1) the impact of P-gp on pharmacokinetics; 2) MDRl … natural killer cells from healthy
individuals having the 7T genotype … that the effect of MDR1 G2677T/C3435T haplotypes on …

… of MDR1 haplotype, we compared the pharmacokinetics and … well associated with the
pharmacokinetics of amlodipine [35]. … a small pool of healthy volunteers, not patients. These …

… This study demonstrates that ABCB1 haplotypes derived … of its pharmacokinetic parameters
in patients, optimizing … as itraconazole, calcium channel blockers such as diltiazem, …

… Effect of ABCB1 (MDR1) haplotypes derived from G2677T/C3435T on the
pharmacokinetics of amlodipine in healthy subjects. Br J Clin Pharmacol 2007; 63: 53-8. …