Effects of thyroid status on regional brain volumes: a diagnostic and genetic imaging study in UK Biobank

T Chambers, R Anney, PN Taylor… - The Journal of …, 2021 - academic.oup.com
… gray matter volumes. We thus set out … diagnosis of hypo- or hyperthyroidism in UK Biobank
was associated with alterations in gray matter volume in adults, hypothesizing that any effects

An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank

SM Smith, G Douaud, W Chen, T Hanayik… - Nature …, 2021 - nature.com
… of the effect sizes for genetic females and genetic males always … of thyroid function modulation
in the brain appears to … and functional MRI studies) that of the 17 regions associated with …

Enhanced brain imaging genetics in UK Biobank

SM Smith, G Douaud, W Chen, T Hanayik… - BioRxiv, 2020 - biorxiv.org
… of the effect sizes for genetic females and genetic males always … of thyroid function modulation
in the brain appears to … and fMRI studies), that of the 17 regions associated with Cluster 2…

Exploring the genetic link between thyroid dysfunction and common psychiatric disorders: A specific hormonal or a general autoimmune comorbidity

S Soheili-Nezhad, E Sprooten, I Tendolkar, M Medici - Thyroid, 2023 - liebertpub.com
… Next to the direct effects of TH on brain, the effects of thyroid dysfunction on … studied the
co-occurrence of thyroid dysfunction and psychiatric disorders in 502,480 subjects of UK biobank

Interactions between age, sex, menopause, and brain structure at midlife: a UK Biobank study

S Than, C Moran, R Beare, AJ Vincent… - The Journal of …, 2021 - academic.oup.com
… age, sex, and brain volumes, adjusted for ApoE ε4 status. We observed an interaction …
to be more vulnerable to the effects of increasing age on brain structure, and this is related …

Thyroid function and mood disorders: a Mendelian randomization study

A Kuś, AD Kjaergaard, E Marouli, F Del Greco M… - Thyroid, 2021 - liebertpub.com
effects of thyroid function on specific MDD and BD subtypes, while reverse MR analyses
were performed to assess the effects … Consortium (PGC) and UK Biobank (UKBB). This meta-…

Cardiac imaging of aortic valve area from 34 287 UK Biobank participants reveals novel genetic associations and shared genetic comorbidity with multiple disease …

A Córdova-Palomera, C Tcheandjieu… - Circulation: Genomic …, 2020 - Am Heart Assoc
… variant effect estimate for the PGS (see Methods). Furthermore, among the UK Biobank
with aortic valve disease as defined by inpatient diagnosis codes. For each SD decrease in the …

Thyroid function in causal relation to MRI markers of cerebral small vessel disease: a mendelian randomization analysis

Y Tian, D Yao, A Jin, M Wang, Y Pan… - The Journal of …, 2023 - academic.oup.com
… the causal effects of genetically predicted thyrotropin (thyroid-… the UK biobank. Thirdly, there
was a lack of sex-stratified summary statistics of genetic instruments for thyroid function and …

Novel genetic variants associated with brain functional networks in 18,445 adults from the UK Biobank

H Foo, A Thalamuthu, J Jiang, FC Koch, KA Mather… - Scientific reports, 2021 - nature.com
… several genes involved in the production of thyroid hormone 24 , essential for brain development
and function … Future studies may benefit from investigating the genetic effects between …

Markers of kidney function, genetic variation related to cognitive function, and cognitive performance in the UK Biobank

EL Richard, LK McEvoy, IJ Deary, G Davies, SY Cao… - BMC nephrology, 2022 - Springer
… causal effects of these kidney function markers. Using genetic data from the UK Biobank,
we recently carried out a one-sample MR study examining the causal effects of eGFRcys, …