… The molecular basis for heart failure is unknown, but oxidative … activity of xanthine
oxidoreductase (XOR)∗, a free-radical generating enzyme, increases in hypertrophied and failing …

… is implicated in cardiac remodeling in heart failure (HF). As xanthine oxidoreductase (XOR) …
This increased expression translated into increased XOR activity in SHHF (54.9±4.1 mU/μg) …

… Oxidative stress due to purine degradation is associated with the development of chronic
heart failure (CHF). Xanthine oxidoreductase (XOR) is a rate-limiting enzyme of purine …

… clinical outcome trials, particularly for congestive heart failure. Here we review XOR gene …
cardiovascular disease with an emphasis on heart failure. Xanthine oxidoreductase (XOR), first …

… failure caused by ischemic heart disease or dilated cardiomyopathy were arrested in situ …
xanthine oxidoreductase activity, we subjected rat hearts (which display a relatively high activity…

… Objective: Xanthine oxidase (XO) inhibitors enhance … whether this inotropic action is
preserved or magnified in failing rat … a markedly greater extent in preparations from failing hearts. …

… Oxidative stress is increased in the failing heart of TO-2 hamsters, 3 as confirmed in the …
extracellular matrix turnover and cardiac remodeling. In the failing heart of animals subjected to …

… ecSOD and increased xanthine oxidase activity contribute to increased vascular oxidative
… Enhanced expression and activity of xanthine oxidoreductase in the failing heart. J Mol Cell …

… Inhibition of xanthine oxidase (XO) in failing hearts improves cardiac efficiency by an …
Enhanced expression and activity of xanthine oxidoreductase in the failing heart. J Mol Cell …

… are increased in the failing heart, providing additional substrate for the purine degradation
pathway. Although XO activity … increased in the vehicle-treated TAC animals is consistent with …