Epidemics as an adaptive driving force determining lifespan setpoints
PV Lidsky, R Andino - … of the National Academy of Sciences, 2020 - National Acad Sciences
… By examining the impact of lifespan on pathogen spread in a population, we propose that
epidemics drive lifespan setpoints’ evolution. Shorter lifespan limits infection spread and …
epidemics drive lifespan setpoints’ evolution. Shorter lifespan limits infection spread and …
Protection from epidemics is a driving force for evolution of lifespan setpoints
PV Lidsky, R Andino - bioRxiv, 2017 - biorxiv.org
… coevolution played a key role in determining the lifespan setpoints of a species. A population
of … Finally, considering lifespan termination as an adaptive trait, our theory does not provide …
of … Finally, considering lifespan termination as an adaptive trait, our theory does not provide …
[PDF][PDF] Adaptive dynamics of infectious diseases
U Dieckmann, JAJ Metz, MW Sabelis… - Pursuit of virulence …, 2002 - iiasa.ac.at
… in host health – so as to promote the life span of the hosts in the absence of the disease – …
, setting off an outbreak of an earlier, competitively inferior strain. An unexpected finding is that …
, setting off an outbreak of an earlier, competitively inferior strain. An unexpected finding is that …
Could aging evolve as a pathogen control strategy?
PV Lidsky, R Andino - Trends in Ecology & Evolution, 2022 - cell.com
… traits but not a programmed adaptive process. Alternatively, … for the evolution of lifespan
set points, and a consensus on the … infectious diseases could shape the evolution of lifespan. …
set points, and a consensus on the … infectious diseases could shape the evolution of lifespan. …
Immunosenescence and inflammaging in the aging process: age-related diseases or longevity?
… adaptive mechanisms generated by immunosenescence and inflammaging determine the
susceptibility to several diseases… the major age-associated diseases. They indeed show a …
susceptibility to several diseases… the major age-associated diseases. They indeed show a …
Altruism and phenoptosis as programs supported by evolution
GA Shilovsky, TS Putyatina, AV Markov - Biochemistry (Moscow), 2021 - Springer
… /IGF-1 could more than double the lifespan (LS) of the nematode … The moving force of evolution
is natural selection of random … We believe that infection outbreaks can promote control of …
is natural selection of random … We believe that infection outbreaks can promote control of …
[图书][B] Human senescence: evolutionary and biocultural perspectives
DE Crews - 2003 - books.google.com
… of life span, chronic degenerative diseases, and adaptability. … across a wide variety of
environmental and cultural settings. … evolutionary history necessarily determine to some degree …
environmental and cultural settings. … evolutionary history necessarily determine to some degree …
Metabolomics of human brain aging and age-related neurodegenerative diseases
M Jové, M Portero-Otín, A Naudí, I Ferrer… - … of Neuropathology & …, 2014 - academic.oup.com
… for the evolution of complex organisms that demand adaptive … is a major driving force in
determining the differential … operate throughout the life span and determine the rate of aging, …
determining the differential … operate throughout the life span and determine the rate of aging, …
The role of declining adaptive homeostasis in ageing
LCD Pomatto, KJA Davies - The Journal of physiology, 2017 - Wiley Online Library
… a lifetime of chronic or excessively repetitive adaptive stimuli, … A major driving force in the
activation of the transient stress … approaches to several diseases. Indeed, multiple chronic …
activation of the transient stress … approaches to several diseases. Indeed, multiple chronic …
[HTML][HTML] The good, the bad, and the ugly of ROS: new insights on aging and aging-related diseases from eukaryotic and prokaryotic model organisms
AL Santos, S Sinha, AB Lindner - … medicine and cellular longevity, 2018 - hindawi.com
… signaling pathways that promote an adaptive response [11, … complex role in determining
longevity than previously thought… ] has been implicated as the driving force in the aging process, …
longevity than previously thought… ] has been implicated as the driving force in the aging process, …