… the aged heart to respond to an ischemic stress is the observation in the current study that
following I/R, aged females have lower levels … Because both PKCδ and PKCε promote cardiac …

… PI3K-Akt-GSK-3β signaling and estrogen – Interestingly, … role for PKCε targeting in the aged,
E 2 -deficient female rat … between age-dependent declines in ischemic tolerance and altered …

… team involving estrogen-deprived female rats demonstrated … of cardiac autonomic regulation
and mitochondrial function, … TNF production, and reduced PI3K and Akt activation which …

… AM, Korzick DH (2007) Estrogen deficiency decreases ischemic tolerance in the aged rat
heart: roles of PKCdelta, PKCepsilon, Akt, and GSK3beta. Am J Physiol Regul Integr Comp …

… in females increases with age, 1 but it is significantly lower than … of the LV function was less
in ovariectomized rats than in … of Akt/PKB and translocation of PKCε and, in male rat hearts, a …

… role is played by Akt. We aimed to investigate in an aging diabetic rat model, the susceptibility
of the heart to … The old, diabetic GK rat hearts have decreased resting cardiac function and …

… function did not vary substantially between young and aged … On the other hand, levels of
the survival kinases AKT, ERK1/2 and … and bcl-2, bcl-xl, bax and fas in the rat heart and brain …

… in ischemic tolerance with increasing age in isolated rat hearts… function in the aged hearts
(21–22 months) suggesting that … Aging also tends to reduce ERK and AKT phosphorylation …

… "Estrogen deficiency decreases ischemic tolerance in the aged rat heart: roles of PKCdelta,
PKCepsilon, Akt, and GSK3beta". Am J Physiol Regul Integr Comp Physiol 2007; 292: R800. …

… We hypothesized that ORX would reduce post I/R cardiac … of isolated male rat hearts from
25-min global ischemia and found … ischemia and found that ORX improved myocardial function …