Evidence that differentiation-inducing factor-1 controls chemotaxis and cell differentiation, at least in part, via mitochondria in D. discoideum

Y Kubohara, H Kikuchi, VH Nguyen… - Biology …, 2017 - journals.biologists.com
… -1)] is an important regulator of cell differentiation and chemotaxis in the development of the
cell differentiation and modulate chemotaxis, at least in part, by disturbing mitochondrial

[HTML][HTML] Differentiation-Inducing Factor-1 and -2 Function also as Modulators for Dictyostelium Chemotaxis

H Kuwayama, Y Kubohara - PLoS One, 2009 - journals.plos.org
… Various indirect evidence suggests that DIFs may have novel … Furthermore, our findings
suggest that cell differentiation … as drugs to control mammalian chemotaxis for basic research …

[HTML][HTML] Control of Cell Differentiation by Mitochondria, Typically Evidenced in Dictyostelium Development

Y Maeda, J Chida - Biomolecules, 2013 - mdpi.com
… multicellular structures by means of chemotaxis toward 3’,5’-… novel protein that binds to tumor
necrosis factor 1 (TNF-1) [28]… It has been shown that differentiation-inducing factors (DIFs) …

The Dictyostelium model for mitochondrial biology and disease

XG Pearce, SJ Annesley, PR Fisher - The International Journal of …, 2019 - ijdb.ehu.es
evidence of mitochondria’s role in differentiationdifferentiation-inducing factors (DIF) (Kubohara
et al., 2017, Thompson and Kay, 2000). These DIFs also are involved in chemotaxis in D

[HTML][HTML] Derivatives of Differentiation-Inducing Factor 1 Differentially Control Chemotaxis and Stalk Cell Differentiation in Dictyostelium discoideum

H Kuwayama, H Kikuchi, Y Kubohara - Biology, 2023 - mdpi.com
… differentially control stalk cell differentiation and chemotaxis. We … have at least three receptors:
DR-1D, responsible for stalk cell … to mitochondria, suggesting that DIF-1 controls stalk cell

[HTML][HTML] Pharmacological Evidence That Dictyostelium Differentiation-Inducing Factor 1 Promotes Glucose Uptake Partly via an Increase in Intracellular cAMP …

Y Kubohara, Y Fukunaga, H Kikuchi, H Kuwayama - Molecules, 2023 - mdpi.com
differentiation, cell death, chemotaxis, and morphogenesis, … isolated as a stalk cell
differentiation-inducing factor in D. … a mitochondrial uncoupler and can promote glucose uptake, at …

The Dictyostelium prestalk inducer differentiation-inducing factor-1 (DIF-1) triggers unexpectedly complex global phosphorylation changes

C Sugden, MD Urbaniak, T Araki… - … Biology of the Cell, 2015 - Am Soc Cell Biol
… of DIF-1 on chemotaxis to cAMP. All MS data are available … been suspected; we present
evidence suggesting that DIF-1 … In addition to potential control of cellular signaling via protein …

On the Evolutionary Conservation of the Cell Death Pathway: Mitochondrial Release of an Apoptosis-inducing Factor duringDictyostelium discoideum Cell Death

D Arnoult, I Tatischeff, J Estaquier… - … biology of the cell, 2001 - Am Soc Cell Biol
… conservation of at least part of the cell death pathway in … cell death induced by
differentiation-inducing factor-1 (DIF-1). … involve cell chemotaxis and aggregation and …

[HTML][HTML] Dictyostelium: An Important Source of Structural and Functional Diversity in Drug Discovery

Y Kubohara, H Kikuchi - Cells, 2018 - mdpi.com
… and functions of polyketide differentiation-inducing factor-1, a … as modulators for Dictyostelium
chemotactic cell movement … 20 µM induces a loss of mitochondrial membrane potential, …

[HTML][HTML] Differentiation-inducing factor 1 activates cofilin through pyridoxal phosphatase and AMP-activated protein kinase, resulting in mitochondrial fission

T Inoue, K Miura, R Han, F Seto-Tetsuo… - Journal of …, 2023 - Elsevier
… produced by Dictyostelium discoideum that inhibits the … exhausted, unicellular cells
differentiate into multicellular fruiting … was performed using anti-HA antibody or control mouse IgG …