[HTML][HTML] GSK-3: a key regulatory target for ketamine's rapid antidepressant effects mediated by enhanced AMPA to NMDA throughput
CA Zarate Jr, R Machado-Vieira - Bipolar disorders, 2016 - ncbi.nlm.nih.gov
… GSK-3 plays a key role in the enhanced AMPA throughput model underlying ketamine’s
rapid antidepressant … to involve AMPA receptor activation potentially mediated by GSK-3, with …
rapid antidepressant … to involve AMPA receptor activation potentially mediated by GSK-3, with …
[HTML][HTML] Ketamine-induced inhibition of glycogen synthase kinase-3 contributes to the augmentation of AMPA receptor signaling
… -aspartate (NMDA) receptor antagonist ketamine fulfills some … GSK3 is a feasible target for
antidepressant effects because … trafficking of AMPA receptors were regulated by GSK3. Wild-…
antidepressant effects because … trafficking of AMPA receptors were regulated by GSK3. Wild-…
[HTML][HTML] Ketamine: synaptogenesis, immunomodulation and glycogen synthase kinase-3 as underlying mechanisms of its antidepressant properties
PA Zunszain, MA Horowitz, A Cattaneo, MM Lupi… - Molecular …, 2013 - nature.com
… that the NMDA receptor may be a useful target for antidepressant … , ketamine can enhance
AMPA receptor throughput. In … that blocks GSK-3 phosphorylation did not respond to ketamine …
AMPA receptor throughput. In … that blocks GSK-3 phosphorylation did not respond to ketamine …
[HTML][HTML] The mechanisms behind rapid antidepressant effects of ketamine: a systematic review with a focus on molecular neuroplasticity
… neurotransmitters, neuromodulatory regulators, or from a trigger … , ketamine administration
also increases the AMPA to NMDA … -95, the target of GSK-3 that would promote AMPA-GluA1 …
also increases the AMPA to NMDA … -95, the target of GSK-3 that would promote AMPA-GluA1 …
The role of NMDA receptor in neurobiology and treatment of major depressive disorder: evidence from translational research
… receptor-mediated intracellular signaling pathways in brain circuits of patients with MDD. …
that NMDA receptor antagonists, particularly ketamine, have rapid antidepressant effects in …
that NMDA receptor antagonists, particularly ketamine, have rapid antidepressant effects in …
Fast-acting antidepressant activity of ketamine: highlights on brain serotonin, glutamate, and GABA neurotransmission in preclinical studies
TH Pham, AM Gardier - Pharmacology & therapeutics, 2019 - Elsevier
… (NMDA) receptor, displays a fast antidepressant activity in … activation of AMPA receptors,
which trigger mammalian target of … It could be also mediated by one or several ketamine …
which trigger mammalian target of … It could be also mediated by one or several ketamine …
[HTML][HTML] Rapid and long-lasting antidepressant-like effects of ketamine and their relationship with the expression of brain enzymes, BDNF, and astrocytes
GSB Viana, EM Do Vale, ARA de Araujo… - Brazilian Journal of …, 2020 - SciELO Brasil
… GSK-3: a key regulatory target for ketamine's rapid antidepressant effects mediated by
enhanced AMPA to NMDA throughput. Bipolar Disord 2016; 18: 702–705, doi: 10.1111/bdi.12452…
enhanced AMPA to NMDA throughput. Bipolar Disord 2016; 18: 702–705, doi: 10.1111/bdi.12452…
[HTML][HTML] The ketamine antidepressant story: new insights
TK Alshammari - Molecules, 2020 - mdpi.com
… The aim of this study was to summarize and highlight the … non-NMDA-mediated affects
of ketamine are summarized in … , AMPA was found to be an essential element in mediating …
of ketamine are summarized in … , AMPA was found to be an essential element in mediating …
New targets for rapid antidepressant action
… downstream-related targets associated with the regulation of rapid … by enhancing AMPA
relative to NMDA throughput in critical … Similarly, ketamine inhibited brain GSK-3 expression, and …
relative to NMDA throughput in critical … Similarly, ketamine inhibited brain GSK-3 expression, and …
Activation of mammalian target of rapamycin and synaptogenesis: role in the actions of rapid-acting antidepressants
JM Dwyer, RS Duman - Biological psychiatry, 2013 - Elsevier
… allow ketamine-like rapid antidepressant effects by targeting … GSK-3 is required for the rapid
antidepressant-like effects of … Ketamine-inhibition of GSK-3 could occur via AMPA receptor …
antidepressant-like effects of … Ketamine-inhibition of GSK-3 could occur via AMPA receptor …