… The genesis of prolactinoma in lactotropes of the pituitary gland … animal studies in which
prolactinoma is induced by estrogen. Animal Model for Studying the Genesis of Prolactinomas …

… as an animal model of human PRL-producing pituitary adenoma in a large number of studies.
… We consider that this animal model is useful for pathogenesis analyses and therapeutic …

… prolactinoma development [47]. The TGFβ1 expression was reduced in human and animal
prolactinomas [… of genes implicated in genesis and progression of prolactinoma, such as Pttg, …

… the physiological effects of prolactinomas and to summarize … Recently phytoestrogen, a
biologically active substance of plant origin, … Anterior pituitaries from estrogen-treated rats can be …

… formation of prolactinomas in both humans and animals [3–5]… fall in serum PRL occurred in
the estrogen-treated rats (Fig. 5). … Since lactotrophs and somatotrophs have a common origin …

… agonist therapy for pituitary prolactinomas results in the … to the Care and Use of Laboratory
Animals. The rats were … Using increasing doses of bromocriptine in estrogen-treated rats…

… However, the natural history of the prolactinoma has not yet … PRLsecreting tumor prompted
studies in an animal model of … secretion in both control and estrogen-treated rats 1 and 10 …

… hyperprolactinemia and formation of prolactinomas (19, 20). … All animal studies were performed
under an institutionally … grafted to the kidney capsule of estrogen-treated recipients (19). …

… The anterior pituitary is of non-neuronal origin and does not … This discrepancy could be
attributed to differences in animal … potent dopamine agonist, to estrogen-treated Fischer 344 rats, …

… human prolactinoma and pituitaries of estrogen-treated ACI rat, … for drug evaluation and for
studying tumorigenesis. Drug … and human prolactinomas and found that both species share …