Genetic background modifies the effects of type 2 cannabinoid receptor deficiency on bone mass and bone turnover
A Sophocleous, AI Idris, SH Ralston - Calcified tissue international, 2014 - Springer
… effects of genetic background on the skeletal phenotype of mice with type 2 cannabinoid
receptor deficiency … We studied Cnr2 −/− mice on a CD1 background and compared the findings …
receptor deficiency … We studied Cnr2 −/− mice on a CD1 background and compared the findings …
Modulation of strain-specific differences in gene expression by cannabinoid type 2 receptor deficiency
… with targeted inactivation of the type 2 cannabinoid receptor (Cnr2 −/− ) … bone mass and
reduced osteoclastic bone resorption … The largest changes were in Cnr2 itself and the interleukin-…
reduced osteoclastic bone resorption … The largest changes were in Cnr2 itself and the interleukin-…
The type 2 cannabinoid receptor regulates bone mass and ovariectomy-induced bone loss by affecting osteoblast differentiation and bone formation
A Sophocleous, E Landao-Bassonga… - …, 2011 - academic.oup.com
… bone mass due to a defect in osteoclastic bone resorption, but … same genetic background
had normal peak bone mass and … The changes in bone mass and bone structure that occurred …
had normal peak bone mass and … The changes in bone mass and bone structure that occurred …
The cannabinoids effect on bone formation and bone healing
B Raphael-Mizrahi, Y Gabet - Current Osteoporosis Reports, 2020 - Springer
… Cannabinoid receptors CB1 and CB2 are expressed in bone and regulate … between the
effect of CB1 and CB2 activation reported using genetically modified animal models. Studies on …
effect of CB1 and CB2 activation reported using genetically modified animal models. Studies on …
Cannabinoids and the skeleton: from marijuana to reversal of bone loss
I Bab, A Zimmer, E Melamed - Annals of medicine, 2009 - Taylor & Francis
… (type 2 cannabinoid receptor) is associated with maintaining … These changes are the
consequence of a continuous … Although the CB1 cannabinoid receptor has been identified in …
consequence of a continuous … Although the CB1 cannabinoid receptor has been identified in …
Bones and joints: the effects of cannabinoids on the skeleton
J Ehrenkranz, MA Levine - … Clinical Endocrinology & Metabolism, 2019 - academic.oup.com
… receptors type 1 (CB1) and type 2 (CB2) (3); transient … no changes in biomechanical
characteristics of femoral bones of … , can influence the effects of cannabinoid receptor signaling on …
characteristics of femoral bones of … , can influence the effects of cannabinoid receptor signaling on …
Association of cannabinoid receptor modulation with normal and abnormal skeletal remodelling: A systematic review and meta-analysis of in vitro, in vivo and human …
A Sophocleous, M Yiallourides, F Zeng… - Pharmacological …, 2022 - Elsevier
… of Cannabis sativa has been implicated in changes in bone … precursor cells by suppressing
cannabinoid receptor type 2. … We observed that genetic inactivation of CB1 receptors in …
cannabinoid receptor type 2. … We observed that genetic inactivation of CB1 receptors in …
Regulation of bone mass, osteoclast function, and ovariectomy-induced bone loss by the type 2 cannabinoid receptor
AI Idris, A Sophocleous, E Landao-Bassonga… - …, 2008 - academic.oup.com
… CB1 deficiency on a CD1 background had high bone mass … changes in nuclear morphology
using 4′,6-diamidino-2-… To minimize the chance of genetic drift, CB2 −/− mice used in …
using 4′,6-diamidino-2-… To minimize the chance of genetic drift, CB2 −/− mice used in …
Peripheral cannabinoid receptor, CB2, regulates bone mass
O Ofek, M Karsak, N Leclerc, M Fogel… - Proceedings of the …, 2006 - National Acad Sciences
… type 1 (CB1) and peripheral cannabinoid receptor type 2 (… These changes are reminiscent
of human osteoporosis and … gene encoding CB2 with postmenopausal osteoporosis (40). …
of human osteoporosis and … gene encoding CB2 with postmenopausal osteoporosis (40). …
[HTML][HTML] The role of cannabinoids in bone metabolism: a new perspective for bone disorders
… on the action of the cannabinoid receptor ligands in skeleton … receptor type 2 (CB2R), which
were isolated and cloned only … in bone by modifying OB and OC differentiation and actions. …
were isolated and cloned only … in bone by modifying OB and OC differentiation and actions. …